ID M7BIJ6_CHEMY Unreviewed; 728 AA.
AC M7BIJ6;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000256|ARBA:ARBA00014590};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE Flags: Fragment;
GN ORFNames=UY3_05013 {ECO:0000313|EMBL:EMP37731.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP37731.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; KB521250; EMP37731.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BIJ6; -.
DR STRING; 8469.M7BIJ6; -.
DR eggNOG; KOG0922; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF234; ATP-DEPENDENT RNA HELICASE DHX40-RELATED; 1.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EMP37731.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EMP37731.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|EMBL:EMP37731.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 11..180
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 212..391
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP37731.1"
FT NON_TER 728
FT /evidence="ECO:0000313|EMBL:EMP37731.1"
SQ SEQUENCE 728 AA; 82651 MW; 59715E59DC4779FA CRC64;
LPIHRYRQKL VDAVRDNSFL IVTGETGSGK TTQLPKYLFE EGFLKHGVIG VTQPRRVATM
SVAQRVAEEM NSSLGSIVGY QVRFDDCTSE GTAIKYMTDG CLLRQILADL HLTKYSVIIL
DEAHERSLST DILFGLLKKL FQQKKPPKRR KALKVVVMSA TLEVDKLSEF FGGCTVVDIP
GRNYPIKEIF CSLLGPKDAE SSAYVTEAVK VTLDIHLNES AGDILVFLTG QSEIERTCDL
LFQKAESIDY RYDVQDGSVE GLLILPLYGS MPTDQQRRIF LPPPPGIRKC VVSTNVAATS
LTVDGIRYVV DSGFVKQLNH NPRVGLDILE VVPISKSEAM QRAGRAGRTS PGKCYRVYSK
EFWDQCMPDH MIPEIKRTSL TSVILTLKCL AVHDVIRFPY LDRPEERHIL EALKQLYQCD
AIDRRGHVTR LGEFLVQFPL PPNLTCAVIK AASLDCEDLL LPIAAMLSVE NVFIRPGDLL
KQKEAELRHQ ELSLEAGGCN DFATLLNIFE QCKSSKSPVA WCQKHWVHFR ALKSAFSVEA
QLQEITSKLK QLSDFPRERF DGSKNEILRR CLCTGYFTNV ARRSAGRTFC TMDGHGSIVH
LHPSSALHDQ ELQPEWIIFH DVLVTSKIYV RMVCPIRYEW VKDLLPKLHE IDVYELSSVA
REEVTEEEIT KWKNKEDLKR QYEKIKDDSA KKMEKRNDDK SIQDARVRYL QRKQQRAQCI
NATLKEIG
//
