ID M7BSA8_CHEMY Unreviewed; 1527 AA.
AC M7BSA8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 12 {ECO:0000313|EMBL:EMP38640.1};
GN ORFNames=UY3_04121 {ECO:0000313|EMBL:EMP38640.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP38640.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; KB518694; EMP38640.1; -; Genomic_DNA.
DR STRING; 8469.M7BSA8; -.
DR eggNOG; ENOG502QS9E; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 6.
DR Pfam; PF05729; NACHT; 2.
DR Pfam; PF17776; NLRC4_HD2; 2.
DR Pfam; PF17779; NOD2_WH; 2.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 13.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 3.
DR PROSITE; PS50837; NACHT; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 1..192
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1039..1237
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1527 AA; 174244 MW; 4D47D0444C44BF71 CRC64;
MTARKIMFDW AAGELYKEKF DYAFYINCRE VNFGSEQGRI ADLILKNCPN KNAPVEEILI
NPEKLLFIID GFDELRFSLD QPEDNLCSDP CEKQPMEITL SSLVRKTVLF ESYVIITTRP
TALEKLRQCL ECARYAEILG FSAAEREEYF HKFFGNEEKA RKAFNFVKEN EMLFTMCFVP
IVCWIICTVL KQQMEAGEDL AQTSKTITGV YMLYLFSLLK GHSSNSKKHT PANLKGLCSL
AADGIWRQKI LFGEEEIKKH GLDISDSLFL NENMFQKDID CECVYSFIHL SFQEFFAALF
YVLEKEETTT VEDSETAMNN VKKLLENYGK SRNYLMLTVR FLFGLLNEER MEDMEKKLSC
KISPKIKPDL LQWVKTKPKI SSLSLESEEL FLEPDEELSS FKRNAEMIYQ LEEFHCLYEI
QEESFVQSAL NRFTELYLAE YNFTKMDQVA LSFCLKNCCK LETLYLNLCT FGFEDPNEDS
LRPPKQPRLL TNGHLTDACY RDLSSALSTK QTLTELDLSM NNLGDSGVRL LCEGLNHPAC
KLQRLGLSNC HLTAMCGGDL SSLLSTKPTL TELDIGENNL GDSGVQLLCE GLKHPHSKLQ
KLRLMNCGLT ASSCGNLSSV LRAKPTLTEL DLVLNNLGEA GGMKLLCEGL KHPDCKLQKL
RLMGCQLTAA CCEDLSSVLS INQTLTELEL RGNLLRDSGV QLLCEGLKHA NCKLQKLGLK
NFLLTDACCE DLAAVLSISD SLTELELGID YLRDSGVQLL CEGLKHPNCK LQKLGLWGCD
LTADCCGDLS SALSTSQYLT ELELGYNEPG DSGVQLLCEG VKHPNCKLQK LGLEHCSLTA
ACCGGLSSAL STNQHLTELD IGRNKLGDTG VQLLCQGLKH PNCKLHKIRT DTKNLLMKFY
GGEAAVDVTI DVFTQINLRD SAAKLKEGKE KDQVFSQSFW FNTSNASCTD LGYRKKYKED
VKNKYEVIQN MTSLTTDNVI LNRRYPKLII LDDPHHAKER EHEIMAMSRR DKEIKTKQAC
SVVTIDTLFT RDKQGQTPQI VVLLGAAGIG KTMTSRKIMY DWAAGELYKK KFDYVFYINC
RETNLIEQGS VVDMIFKNWP NTNAPVNEIL MKPEKLLFII DGFDELRFSF DQTENLCSDP
WEKKPVEIIL SSLFRKKILP QSYLLITSRP TALEKLLQCL ECSRYAEIQG FSEADRKEYF
HKFFGNKEQA RQALQFVKAN DILFTMCFIP IMCWIICTVV KQQFEKGEDL AQTSKSVTGV
YMLYLSSLVK PVSSNLKQHM QANLRGLCSL AAYGVWKRKI LFEEAELKKF GLNQTDSFPL
SLNKDIFQKD IDCVNAYSFI HLSFQEFFAA LFYVLEEDEE TMEDSGTPKK DVKTLLENYG
NSRNYLMLTV RFLFGLLNEE RMQIMEEKFS CKISPKIKPD LLKWVQTNQQ KYLPLSNVHQ
ETRHIYNLEE FHCMFEMYEE NFVRSALDQL TALTLNSNKL TQMDQMAFSF CIKNCHRLES
LCISCCTFAF EDHGEDMLPR RQKWLYQ
//
