ID M7BTS7_CHEMY Unreviewed; 663 AA.
AC M7BTS7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=GTP-binding protein SAR1a {ECO:0000256|ARBA:ARBA00040180};
DE EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
GN ORFNames=UY3_02204 {ECO:0000313|EMBL:EMP40604.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP40604.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBUNIT: Interacts with B3GAT1. {ECO:0000256|ARBA:ARBA00038792}.
CC -!- SIMILARITY: Belongs to the PPase family.
CC {ECO:0000256|ARBA:ARBA00006220}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. SAR1 family.
CC {ECO:0000256|ARBA:ARBA00007507, ECO:0000256|RuleBase:RU003926}.
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DR EMBL; KB508622; EMP40604.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BTS7; -.
DR STRING; 8469.M7BTS7; -.
DR eggNOG; KOG1626; Eukaryota.
DR eggNOG; KOG3656; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006796; P:phosphate-containing compound metabolic process; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR CDD; cd00412; pyrophosphatase; 1.
DR CDD; cd00879; Sar1; 1.
DR Gene3D; 3.90.80.10; Inorganic pyrophosphatase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008162; Pyrophosphatase.
DR InterPro; IPR036649; Pyrophosphatase_sf.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR InterPro; IPR006687; Small_GTPase_SAR1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45684:SF6; GTP-BINDING PROTEIN SAR1A; 1.
DR PANTHER; PTHR45684; RE74312P; 1.
DR Pfam; PF00025; Arf; 1.
DR Pfam; PF00719; Pyrophosphatase; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF50324; Inorganic pyrophosphatase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51417; ARF; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00387; PPASE; 1.
DR PROSITE; PS51422; SAR1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU003926};
KW ER-Golgi transport {ECO:0000256|RuleBase:RU003926};
KW Golgi apparatus {ECO:0000256|RuleBase:RU003926};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein transport {ECO:0000256|RuleBase:RU003926};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003926}.
FT TRANSMEM 69..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..129
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 143..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 74112 MW; 2F746960DAADC359 CRC64;
MPWKRFDVNH IIPLPNGGSR VYSSKFLFPV WNIFLPSNSS SPYSKNNSRI RVFREKYAFS
SHYQHSAPIA ALFLLAYILI FLMCMTGNML PGVTVLTNRQ MWTVTNMFIL NLAIRDLLVG
TFCMPTTLVD NLITVPKKKL KKRSPSALKD RAASGKGPLS GHAPATDSHR GTAEVEPTSP
AKDPLHTPDS GKGSQPVMRP AVPETVSAAK EQGRLTPQVS RQNVFNMVVE VPRWTNAKME
IATKDPLNPI KQDVKKGQLR YVANVFPHKG YIWNYGAIPQ TWENPRHKDE NTGYYGDNDP
IDVCEIGSKI CSRGEVIKVK VLGTLALIDE GETDWKVIAI NIEDPEAASY NNIDDVRKIK
PGYLEATVDW FRRYKIPDGK QENQFAFNGE FKDKDFAINI IKSTHEHWTA LISKKTDGGE
INCANTTVSD SAFCISQESA KATVEAVPPC GTPNTIPPEG NKSSTMSFIF EWIYNGFSSV
LQFLGLYKKS GKLVFLGLDN AGKTTLLHML KDDRLGQHVP TLHPTSEELT IAGMTFTTFD
LGGHEQARRV WKNYLPAING IVFLVDCADH SRLMESKVEL NALMTDETIS NVPILILGNK
IDRPEAISEE KLREIFGLYG QTTGKGNVPL KDLNTRPMEV FMCSVLKRQG YGEGFRWLSQ
YID
//
