ID M7C1L6_CHEMY Unreviewed; 516 AA.
AC M7C1L6;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Rho guanine nucleotide exchange factor 19 {ECO:0000313|EMBL:EMP42070.1};
GN ORFNames=UY3_00660 {ECO:0000313|EMBL:EMP42070.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP42070.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB478633; EMP42070.1; -; Genomic_DNA.
DR AlphaFoldDB; M7C1L6; -.
DR STRING; 8469.M7C1L6; -.
DR eggNOG; KOG3523; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11940; SH3_ARHGEF5_19; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF6; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 52..236
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 429..490
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 516 AA; 58494 MW; D7F02F7513961C2E CRC64;
MALVPTLEPS LGDSQYSPSG WGVGKAAPAK QSHFSRLQQP LLLFPPPSGG GQLLQAKFEL
ITSEASYIHS LSIAVQHFMN SRELNECLGA QEKQWLFSKL PEVKDVSERF LLELEERLEE
NILHFDICDI VLRHCPAFRR VYLPYVTNQA YQEQTYQRLL QDNPKFPGIL AKLEEGPMCQ
RLPLTSFLIL PFQRVMRLQM LVENILKRTL QGSRDEATAT KAFNQLKKLV KECNASVQSM
KRTEELIHLN KKIHFESKIF PLISQSRWLV KHGELVEVDM QLISTLAAKF KLSTKMVYLH
LFNDCLLLSR RKESSVSCSP GVSACHAPAL SSGRCCPSVT VSLPLPVSPR TGKFAVFVHA
KMPELKVTDL SRKLHGVPGQ IFHLQLFDSQ RLKHQVLLRA QTESEKQRWI SAMVPSSPQT
DREHVTENAD TAQVQCIKAY KAQEHDELTL EKADILGVKT RTSDGWVEGI RLSDGERGWV
PQGHVEEITS RGARLRNLRE NDRIKHATSK LEEEQA
//
