ID M7NM13_PNEMU Unreviewed; 785 AA.
AC M7NM13;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Tr-type G domain-containing protein {ECO:0000259|PROSITE:PS51722};
GN ORFNames=PNEG_03405 {ECO:0000313|EMBL:EMR08237.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR08237.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR08237.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFWA02000017; EMR08237.1; -; Genomic_DNA.
DR RefSeq; XP_007875490.1; XM_007877299.1.
DR AlphaFoldDB; M7NM13; -.
DR STRING; 1069680.M7NM13; -.
DR GeneID; 19897092; -.
DR VEuPathDB; FungiDB:PNEG_03405; -.
DR eggNOG; KOG0458; Eukaryota.
DR HOGENOM; CLU_007265_3_2_1; -.
DR OrthoDB; 5477300at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0002181; P:cytoplasmic translation; IEA:UniProt.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd16267; HBS1-like_II; 1.
DR CDD; cd04093; HBS1_C_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015033; HBS1-like_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF188; HBS1-LIKE PROTEIN; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR Pfam; PF08938; HBS1_N; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 359..573
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 785 AA; 89056 MW; C7507886FFDFF025 CRC64;
MSWRSYFGQE LDDFSADNLE DFSQEELEKL TWTSAKVRER LKDVLHVKQK DIQEALKYCC
FDIDKACSRI IEKKHLKEGL NINKTPSKKG FISFNNSSLN KEDLKSHFNL EVSSEENASE
TKEVSGPKQS KLIALASSKH KLSSNNPISS SLKSVSLLSH LTREKFKATN NRENNNNSSK
IILDIQTNFA KPDVEKDLNL LKTTSEEDQK EEVIDDSLNV FFKKNCEYNI EVKPSKFALT
IFGEKLELPD YFYKFANQRF SLFTGVLEDD LKISLNETFN NSLKSQKKKE KKLKTPSIVK
SPIYSEIISN KDDLHHILNT LNISSEQGDK DETNYDKFYK LSESKNKISN LKTANIKNKP
NVNIVIIGHV DAGKSTLIGR LLYDLKVVDT ETIEKLKRET NKLGKPSFHF AWVLDQTSEE
RDRGVTMDLG INYFETSLRR YTILDTPGHK DFIPNMIAGA SQADVALLVI DASYGSFESG
FTAHGQTREH VILARSLGIQ KIVVAINKLE TTNWSQERYE DIMAQMLQFF IYKGFQKSNI
SFIPCSGLTG ENLTNTIPLN PQLKLWYSNF TLLDTLENIS INRQQLDTFL RLSIMDVYKS
SNTLISVVGR IETGIINVGK EVIIMPSRKN GIIESIYIHD NLQDLAFSGD EVLINLLNID
LSYLKPGDII CDLENPVQIV SKFRAKIITF DLSRPLIIGT PLIIYRGRLN VDGNIKKLIS
IIDKSTGQVK KKDPKFIGSF DAAIVEIEFC KQAEAMESFK HCKELGRFIA RSQGETVAAG
IIEDE
//
