ID M7NY31_9GAMM Unreviewed; 270 AA.
AC M7NY31;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Lipopolysaccharide export system protein LptA {ECO:0000256|HAMAP-Rule:MF_01914};
DE Flags: Precursor;
GN Name=lptA {ECO:0000256|HAMAP-Rule:MF_01914};
GN ORFNames=MPL1_03318 {ECO:0000313|EMBL:EMR13713.1};
OS Methylophaga lonarensis MPL.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Methylophaga.
OX NCBI_TaxID=1286106 {ECO:0000313|EMBL:EMR13713.1, ECO:0000313|Proteomes:UP000012019};
RN [1] {ECO:0000313|EMBL:EMR13713.1, ECO:0000313|Proteomes:UP000012019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MPL {ECO:0000313|EMBL:EMR13713.1,
RC ECO:0000313|Proteomes:UP000012019};
RX PubMed=23661481;
RA Shetty S.A., Marathe N.P., Munot H., Antony C.P., Dhotre D.P.,
RA Murrell J.C., Shouche Y.S.;
RT "Draft Genome Sequence of Methylophaga lonarensis MPLT, a Haloalkaliphilic
RT (Non-Methane-Utilizing) Methylotroph.";
RL Genome Announc. 1:E00202-13(2013).
CC -!- FUNCTION: Involved in the assembly of lipopolysaccharide (LPS).
CC Required for the translocation of LPS from the inner membrane to the
CC outer membrane. May form a bridge between the inner membrane and the
CC outer membrane, via interactions with LptC and LptD, thereby
CC facilitating LPS transfer across the periplasm. {ECO:0000256|HAMAP-
CC Rule:MF_01914}.
CC -!- SUBUNIT: Component of the lipopolysaccharide transport and assembly
CC complex. {ECO:0000256|HAMAP-Rule:MF_01914}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|HAMAP-Rule:MF_01914}.
CC -!- SIMILARITY: Belongs to the LptA family. {ECO:0000256|HAMAP-
CC Rule:MF_01914}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR13713.1}.
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DR EMBL; APHR01000015; EMR13713.1; -; Genomic_DNA.
DR RefSeq; WP_009725694.1; NZ_APHR01000015.1.
DR AlphaFoldDB; M7NY31; -.
DR STRING; 1286106.MPL1_03318; -.
DR PATRIC; fig|1286106.3.peg.662; -.
DR eggNOG; COG1934; Bacteria.
DR eggNOG; COG4991; Bacteria.
DR OrthoDB; 9795964at2; -.
DR Proteomes; UP000012019; Unassembled WGS sequence.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:InterPro.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0015920; P:lipopolysaccharide transport; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.450.10; Lipopolysaccharide (LPS) transport protein A like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR HAMAP; MF_01914; LPS_assembly_LptA; 1.
DR InterPro; IPR014340; LptA.
DR InterPro; IPR005653; OstA-like_N.
DR InterPro; IPR003646; SH3-like_bac-type.
DR NCBIfam; TIGR03002; outer_YhbN_LptA; 1.
DR PANTHER; PTHR36504; LIPOPOLYSACCHARIDE EXPORT SYSTEM PROTEIN LPTA; 1.
DR PANTHER; PTHR36504:SF1; LIPOPOLYSACCHARIDE EXPORT SYSTEM PROTEIN LPTA; 1.
DR Pfam; PF03968; LptD_N; 1.
DR Pfam; PF08239; SH3_3; 1.
DR SMART; SM00287; SH3b; 1.
PE 3: Inferred from homology;
KW Periplasm {ECO:0000256|ARBA:ARBA00022764, ECO:0000256|HAMAP-Rule:MF_01914};
KW Reference proteome {ECO:0000313|Proteomes:UP000012019};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_01914};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01914}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01914"
FT CHAIN 23..270
FT /note="Lipopolysaccharide export system protein LptA"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01914"
FT /id="PRO_5009017552"
FT DOMAIN 206..265
FT /note="SH3b"
FT /evidence="ECO:0000259|SMART:SM00287"
FT REGION 157..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 270 AA; 29954 MW; 952A6BFD2C243831 CRC64;
MRHLKTKLAI SLMLLMPAMS WALPSDREQP INIEADHAQM DDQRGVTQYK GRAILTQGTL
RIEGDVITFF YDAERNLEKA IAEGDLAYYE QVHKEGETPV KAKALQMEYH AGKQMIYLIG
KGHVWQNNDE FTGNYIEYDI ERDLVIANAR PVVIGDTEQP STGRVHITIQ PPGRKPSTTA
PTTAPTTPAP APLVPAPEQS GEQSYPTGTT NTTLNVRTGP GTQYNRIAAF APNTQVVIIT
RQGDWLQVRG IANEQVVIGW VSSRYIDAQN
//
