ID   M7P073_9GAMM            Unreviewed;       606 AA.
AC   M7P073;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   ORFNames=MPL1_07932 {ECO:0000313|EMBL:EMR12882.1};
OS   Methylophaga lonarensis MPL.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC   Piscirickettsiaceae; Methylophaga.
OX   NCBI_TaxID=1286106 {ECO:0000313|EMBL:EMR12882.1, ECO:0000313|Proteomes:UP000012019};
RN   [1] {ECO:0000313|EMBL:EMR12882.1, ECO:0000313|Proteomes:UP000012019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MPL {ECO:0000313|EMBL:EMR12882.1,
RC   ECO:0000313|Proteomes:UP000012019};
RX   PubMed=23661481;
RA   Shetty S.A., Marathe N.P., Munot H., Antony C.P., Dhotre D.P.,
RA   Murrell J.C., Shouche Y.S.;
RT   "Draft Genome Sequence of Methylophaga lonarensis MPLT, a Haloalkaliphilic
RT   (Non-Methane-Utilizing) Methylotroph.";
RL   Genome Announc. 1:E00202-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMR12882.1}.
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DR   EMBL; APHR01000039; EMR12882.1; -; Genomic_DNA.
DR   AlphaFoldDB; M7P073; -.
DR   STRING; 1286106.MPL1_07932; -.
DR   PATRIC; fig|1286106.3.peg.1590; -.
DR   eggNOG; COG0210; Bacteria.
DR   eggNOG; COG1061; Bacteria.
DR   Proteomes; UP000012019; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR011528; NERD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF13245; AAA_19; 1.
DR   Pfam; PF08378; NERD; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000012019}.
FT   DOMAIN          3..99
FT                   /note="NERD"
FT                   /evidence="ECO:0000259|Pfam:PF08378"
FT   DOMAIN          419..526
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13361"
FT   DOMAIN          541..589
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13538"
SQ   SEQUENCE   606 AA;  69375 MW;  DC6B6C8DEA514AD8 CRC64;
     MTSGEKRFAS RLRSFLEDDY LCWYDIPLGR HRRYPDFIIL HPSRGLLFLE VKDWKASSIK
     KISKETVELL TNNGLKTVAN PFVQVRQYAY QGLRLLEADE ALRQQDSRYK GNLVTPFAHG
     VVFTNITRNQ IEAAIAPEYR EKLLPDHLVI YKDEMTESVD PEAFQKQLWD MFPYTFHTKL
     TLPQIDRIRW HLFPEVRIAQ PSQENLFDDS PNQASSSEEL LTASRQIPDI IRIMDIQQEQ
     LARSLGEGHR VIHGVAGSGK TLILGYRAEL LAKITSKPVL VLCFNITLAA KLRSWMEGKG
     IVDKVNVYHF HDWCNQQLKT YHVDVVPGEE PYWERLVMSV IQGVNSEQIP RAQYSAVLID
     EGHDFEADWL RLIVQMLDPE TNSLLLLYDD AQSIYQKKSG LSFSLSSTGI QAQGRTTILK
     LNYRNTQEIL AFAYDFAKEY FGTDKADAEI PLIQPEAAGI HGERPSVHFL KKWQDEIDDA
     ISCLKRWHQR GGQWREMAVL YAANYQGKAI AEALKQHGIP HAWLGSKETK KAYNPAYDRV
     SVLSIHSSKG LEFPAVIMVG ISQLKQDDIN AEARLLYVGM TRAQKHLHLT VSQKNQLTER
     ILEIAS
//