ID M7PF05_PNEMU Unreviewed; 739 AA.
AC M7PF05;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Origin recognition complex subunit 4 C-terminal domain-containing protein {ECO:0000259|Pfam:PF14629};
GN ORFNames=PNEG_02816 {ECO:0000313|EMBL:EMR09044.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR09044.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC4 family.
CC {ECO:0000256|ARBA:ARBA00005334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR09044.1}.
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DR EMBL; AFWA02000007; EMR09044.1; -; Genomic_DNA.
DR RefSeq; XP_007874850.1; XM_007876659.1.
DR AlphaFoldDB; M7PF05; -.
DR STRING; 1069680.M7PF05; -.
DR GeneID; 19896505; -.
DR VEuPathDB; FungiDB:PNEG_02816; -.
DR eggNOG; KOG2228; Eukaryota.
DR HOGENOM; CLU_375571_0_0_1; -.
DR OrthoDB; 230201at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958}.
FT DOMAIN 511..717
FT /note="Origin recognition complex subunit 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14629"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..37
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 85885 MW; CE340CC43C030464 CRC64;
MKKYTYFSSN DQSQDELSFL FPKKQKKRKR NERIRKTSVK KAKIEEIHKI QENKRHHFES
VSQNISSSLF NEEEDELTGN NDFITTKTFS NKKHGKRDSR KLIEISNKHK ANHKVENIFD
GVFSKAKKKT IKNTTFFQES DQLENINIEE CIEVELSEDA NKRMDNLDFW YDDAKISNKE
QDPIDIFSDD PLTSPFANTY TLSVKKEHKK SPKLEDSKNL SKNFDVIINS NATNYNNEND
LNLVSNRLND SFEGLFKEKI NYEYEKKQDI TESKSIFNNF KSHILEKLTG RKYVPIIGLD
SEYTKLRELL YRTINSGESN TCLIIGPKSS GKSNIIDTAI DSLSEFSSYF FVVRLNGIIQ
TDDRLALKEI ARQLNVKMNL DDKENTTSSF SDNLFKILAI LSHPKELDLV NDNKTSEEFD
SSYNPLSPNN ITFVSVIFIL DNFDLFTQHH RQTLLYNLFD ISQTKKAPIA VIGLTCSLDS
VESLEKRVKS RFSHRIIQIK HPDNLELFTK VCQSGLTIDY ESPPELSLKE KEMELRFIKS
WNKQINDLFQ EGNAVYQLVK KLFMTSKDVR IFYSHCIIPI ISLSSPSLSN LQEKLFFSEN
FFNSYNKITY LNGISLLQLS LLICAARIDT RDVDTFNFNM VYKEYYELVT KTTSSSTLSV
IKNTSIRLWE RDILLDAWEK LCNSNFLQPC NTNLTNIGGL DRECRMYRVE IILMDLISYI
EKVKTIPTIL KRWSKDVVA
//
