ID M7PH02_PNEMU Unreviewed; 615 AA.
AC M7PH02;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Fimbrin {ECO:0008006|Google:ProtNLM};
GN ORFNames=PNEG_01919 {ECO:0000313|EMBL:EMR09734.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR09734.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR09734.1}.
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DR EMBL; AFWA02000009; EMR09734.1; -; Genomic_DNA.
DR RefSeq; XP_007873895.1; XM_007875704.1.
DR AlphaFoldDB; M7PH02; -.
DR STRING; 1069680.M7PH02; -.
DR GeneID; 19895613; -.
DR VEuPathDB; FungiDB:PNEG_01919; -.
DR eggNOG; KOG0046; Eukaryota.
DR HOGENOM; CLU_015284_3_0_1; -.
DR OMA; WQLMRKN; -.
DR OrthoDB; 5475188at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProt.
DR CDD; cd21294; CH_FIMB_rpt1; 1.
DR CDD; cd21300; CH_FIMB_rpt3; 1.
DR CDD; cd21303; CH_FIMB_rpt4; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961:SF18; FI19014P1; 1.
DR PANTHER; PTHR19961; FIMBRIN/PLASTIN; 1.
DR Pfam; PF00307; CH; 4.
DR SMART; SM00033; CH; 4.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..51
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 115..235
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 263..366
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 386..495
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 508..615
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 615 AA; 70012 MW; 45DC3012430B3237 CRC64;
MNIEKLQFKF PNLSQENLFG LINDFKKLDI DGKGYVDKHT IVKAVEYYGE RKSYDEVRAT
LKECHLDSSG RVEVEDYIEE MTKLREGRNR GAFEVNKNRI TVQGSSANVT HTINEDERKE
FTRHINLVLG QDEDMRDRLP FPEDTMQIFD ECRDGLVLSK LINDSVMDTI DERVLNKPSH
GRPINNFQMT ENNNIVINSA KAIGCSVVNI GAQDLIDGKE HLILGLIWQI IRKGLLSKID
IKLHPELYRL LEEDETLEQF LRLPPEQILL RWFNFHLNTA KWDRRVTNFS SDVSDGENYI
ILLNQLKPNE CTRDSLKTMD LLKRAEEILQ SAEKIGCRKY LTPAALVSGN PKLNLAFVAH
LFNTYPGLEP LGEEFPKIED YDAEGEREAR VFTLWLNSLD VDPVVVDLFE DLKNGLVLLQ
AYDKVIKNSV NWRRVSKPKD GIELSRFKCV ENANYAVELG KGCGYSLVGI QGADIVDGSK
TLTLALVWQL MRQNIIQTLS SLSKDGKEIT DSDMVLWCNQ MSRKGGKTST IKNFKDPCLR
NGIFLLDVLN GLRSDYVDYN LVTSGVSYED AFLNAKLAIS IARKYGALIF LVPEDIVDVR
SRLILTFIGS LMALQ
//
