ID M7PI20_9GAMM Unreviewed; 1072 AA.
AC M7PI20;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase {ECO:0000313|EMBL:EMR13545.1};
GN ORFNames=MPL1_04477 {ECO:0000313|EMBL:EMR13545.1};
OS Methylophaga lonarensis MPL.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Methylophaga.
OX NCBI_TaxID=1286106 {ECO:0000313|EMBL:EMR13545.1, ECO:0000313|Proteomes:UP000012019};
RN [1] {ECO:0000313|EMBL:EMR13545.1, ECO:0000313|Proteomes:UP000012019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MPL {ECO:0000313|EMBL:EMR13545.1,
RC ECO:0000313|Proteomes:UP000012019};
RX PubMed=23661481;
RA Shetty S.A., Marathe N.P., Munot H., Antony C.P., Dhotre D.P.,
RA Murrell J.C., Shouche Y.S.;
RT "Draft Genome Sequence of Methylophaga lonarensis MPLT, a Haloalkaliphilic
RT (Non-Methane-Utilizing) Methylotroph.";
RL Genome Announc. 1:E00202-13(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR13545.1}.
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DR EMBL; APHR01000020; EMR13545.1; -; Genomic_DNA.
DR AlphaFoldDB; M7PI20; -.
DR STRING; 1286106.MPL1_04477; -.
DR PATRIC; fig|1286106.3.peg.898; -.
DR eggNOG; COG5001; Bacteria.
DR Proteomes; UP000012019; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF13426; PAS_9; 2.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000012019};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 302..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 324..377
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 389..457
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 582..633
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 665..798
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 807..1061
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 1072 AA; 119678 MW; 50624D5FB407CE9F CRC64;
MIIAAVSLYS NLRYAENQRV LIEQVLPLED NSRQISSISA AFVLRQQQIL NAVNETQLEQ
VIDRNTLETD FEHYWQRLSQ SSHKLNSGEA LVDELYQHYQ QFLLLDTQLS ALMSEKLLLA
EQINEQQAIV DELEARSLEL VARLSLIYQP LAERVRVQMS AQLQTVSFAL LKLTADIRAL
IHTAVNSSAD VDSLILSTQT SDQSLQSAIQ SLEQAGSGLD VLAELSEHRV SLAATSLGAD
NGISRLRQLQ VENSQQLGAN QRQISALLEQ MSADLSSLSR AINHYSLQTV DRSSLIADSA
RGLIIGLTIL VVLAMFWFSL TVSNRIAQPL NRLREAMHAL SSKQFDTRLT AQTGAAEFNL
LAKDFNQFAE NNQTLINDLA EAKHSLQVRE QHIRAILNGV PEAILTLNNE GMITACNPAV
EKVLHATEQQ LVGQPLSRFL DGTAALLMPE KLHLLQKKHR EFDGYDFNGD VISMWLSLSP
VSSIDGDLWV CVISDITDWK ETRLQLQQRT SELDAILENA MVGIAFIKDR HLIRVNHKFE
QLFGCSRAQI EGESAMYLHP SLEAFVQFGE NAYSALAQGE DFEAQVEMVR MSGQRFWCAV
AGKAIDPESP AEGSIWLFED VTKQRENEER LTRLANADVL TGLPNRAVFN DRLEHAIHKA
HRNSGRLAVF FLDLDHFKHI NDSLGHKVGD MLLCEVAKRI RSCVREGDTV ARLGGDEFTV
ILEDVRSAQY VGKVAEKILN TAALPYLLDG TEVNISPSIG ISLYPADGRD VDMLIRNADA
AMYHAKNSGR NNFQFYSADM NAEAAQRLAL ETSLRRAVEQ NEFYLHFQPQ IDLDSGRISG
AEVLLRWHTE HWGEVSPSRF VPLLEDTGLI NTVGEWVLRE TCRQFVESSA DLPDDFVMAV
NLSGRQFKGG HLARYIQNLL LESGMSAKNL ELEITESLLM DDTELAIDTL RQLSALGVTL
AIDDFGTGYS SLSYLKQFPL NVLKIDRTFV SDVTDDKDDA AIVNAILAMS ESLDLEVVAE
GVETAEQLAF LRAQNCKRAQ GYLFSRPVPI EELMQLVDKR ISLPQTVEQA VH
//
