ID M7RRE3_SALDU Unreviewed; 613 AA.
AC M7RRE3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Sensor protein {ECO:0000256|PIRNR:PIRNR003167};
DE EC=2.7.13.3 {ECO:0000256|PIRNR:PIRNR003167};
GN ORFNames=A670_00379 {ECO:0000313|EMBL:EMR54383.1};
OS Salmonella enterica subsp. enterica serovar Dublin str. UC16.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=1192688 {ECO:0000313|EMBL:EMR54383.1, ECO:0000313|Proteomes:UP000013259};
RN [1] {ECO:0000313|EMBL:EMR54383.1, ECO:0000313|Proteomes:UP000013259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UC16 {ECO:0000313|EMBL:EMR54383.1,
RC ECO:0000313|Proteomes:UP000013259};
RA McClelland M., Porwollik S., Desai P., Cheng P., Wollam A., Pepin K.,
RA Bhonagiri V., Fulton L., Fulton R., Delehaunty K., Fronick C., Godfrey J.,
RA Waligorski J., Appelbaum E., Tomlinson C., Warren W., Sodergren E.,
RA Weinstock G., Wilson R.K.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085,
CC ECO:0000256|PIRNR:PIRNR003167};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR54383.1}.
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DR EMBL; APMR01000008; EMR54383.1; -; Genomic_DNA.
DR AlphaFoldDB; M7RRE3; -.
DR PATRIC; fig|1192688.3.peg.363; -.
DR HOGENOM; CLU_000445_20_10_6; -.
DR Proteomes; UP000013259; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:UniProtKB-UniRule.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR CDD; cd22900; NarX_sensor; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 1.20.120.960; Histidine kinase NarX, sensor domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR029095; NarX-like_N.
DR InterPro; IPR042295; NarX-like_N_sf.
DR InterPro; IPR016380; Sig_transdc_His_kin_NarX/NarQ.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF51; NITRATE_NITRITE SENSOR PROTEIN NARX; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF13675; PilJ; 1.
DR PIRSF; PIRSF003167; STHK_NarX/NarQ; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR003167};
KW Cell inner membrane {ECO:0000256|PIRNR:PIRNR003167};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR003167};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR003167};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR003167};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR003167};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR003167};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012,
KW ECO:0000256|PIRNR:PIRNR003167}.
FT TRANSMEM 30..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..243
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 408..602
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 613 AA; 69173 MW; 3A3F5FFD14C91B3C CRC64;
MLRFFGDITP KKEGNMFKRC FSPLTLVNQL ALIVMLSTAI GVAGMAVSGW LVQGVQGSAH
AINKAGSLRM QSYRLLAAVP LDAKDQKLLD EMEQTAFSPE LTRAAERDGQ QKQLKALQDY
WHNELSPGLQ HAQNAHAVAE DVTRFVAGLD RLVTSFDHTT ELRIERVVLV HRVMAIFMAL
LLVFTIIWLR VRLLQPWKQL LSMARAVSQR DFTQRANISG RNEMAALGSA LNNMSEELAE
SYAVLEQRVQ EKTAGLEHKN QILSFLWQAN RRLHSQAPLC ERLSPVLNGL QNLTQLHDIE
LRVYDLEDED NHQEFTCQSD ISCDDKGCHL CPRSALPMIN GGTTLKWRLT DSHTQYGILL
ATLPYGRHLS HDQQQLVDTL VEQLTATLAL DRHQERQQQL IVMEERATIA RELHDSIAQS
LSCMKMQVSC LQMQGDVLPE SSRELLSQIR NELNCSWAQL RELLTTFRLQ LTEPGLRPAL
EASCQEFSAR FGFTVKLDYQ LPPRLVPSHQ AIHLLQIARE ALSNALKHSH ADDVVVTVTQ
CGKQVKLKVQ DNGCGVPENA ERSNHYGMII MRDRAQSLRG DCQVRRRETG GTEVTVTFIP
ETNFTETQGD THE
//
