ID M7SUZ7_EUTLA Unreviewed; 673 AA.
AC M7SUZ7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Probable Xaa-Pro aminopeptidase P {ECO:0000256|ARBA:ARBA00020658};
DE AltName: Full=Prolidase {ECO:0000256|ARBA:ARBA00032413};
GN ORFNames=UCREL1_4910 {ECO:0000313|EMBL:EMR68082.1};
OS Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa
OS armeniacae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Diatrypaceae; Eutypa.
OX NCBI_TaxID=1287681 {ECO:0000313|EMBL:EMR68082.1, ECO:0000313|Proteomes:UP000012174};
RN [1] {ECO:0000313|Proteomes:UP000012174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCR-EL1 {ECO:0000313|Proteomes:UP000012174};
RX PubMed=23723393; DOI=10.1128/genomeA.00228-13;
RA Blanco-Ulate B., Rolshausen P.E., Cantu D.;
RT "Draft genome sequence of the grapevine dieback fungus Eutypa lata UCR-
RT EL1.";
RL Genome Announc. 1:E0022813-E0022813(2013).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR EMBL; KB706307; EMR68082.1; -; Genomic_DNA.
DR RefSeq; XP_007792825.1; XM_007794634.1.
DR AlphaFoldDB; M7SUZ7; -.
DR STRING; 1287681.M7SUZ7; -.
DR KEGG; ela:UCREL1_4910; -.
DR eggNOG; KOG2413; Eukaryota.
DR HOGENOM; CLU_011781_2_2_1; -.
DR OMA; EPGMILS; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000012174; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:EMR68082.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:EMR68082.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000012174}.
FT DOMAIN 66..200
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 381..598
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 611..672
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 673 AA; 74084 MW; BE07927162887C90 CRC64;
MQFRPVFSAV SRAISRTAFS AVSPRPCPNL VTGTGNIRLT ATTNLNIRLR STAVIRMDKV
DTTAQLSQLR QLMDANKVDV YIVPSEDSHS SEYIADCDAR RAFISGFSGS AGCAVVTLDK
AALATDGRYF NQASKQLDGN WLLLKQGIQD VPTWQEWTAE QSAGGKIVAV DPTLLTSNVA
KKLLEKIKKS GGKDLVPLAG NLVDQVWGDE RSARPSEPVI VLGQQFSGKD VTTKLTELRK
ELDKNKSLGF VVSMLDEVAW LFNLRGNDIP YNPVFFSYAI ITPDEATLYV DSSKLDPGCQ
SYLDKNGVSV KPYHAIFEDA TALSQSARSA NAEDSGEQKK FIISNRASWA LKRALGGDAM
VTELRSPISD AKAIKNDTEL EGMRSCHVRD GAALIEYFAW LEDQLIQKKA QIDEVEGADK
LESLRAKQKD YVGLSFDTIS STGANAAVIH YKPQPGKCAT IDSNAVYLCD SGAQYLDGTT
DVTRTLHFGN PTDAEIEAYT LVLQGNIALD MAVFPKGTTG FALDCLARQH LWRQGLDYRH
GTGHGVGSYL NVHEGPIGIG TRIQFSEVPL SPGNVISNEP GFYVDGSFGI RIENIIMARE
VKTKHSFGDR PYLGFEHVTM VPYCRKLIDP SLLTNVERQW LNEYNADIWN KTKGYFEGDQ
LTLAWLERET QAF
//
