ID M7TYS4_BOTF1 Unreviewed; 521 AA.
AC M7TYS4;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=BcDW1_4854 {ECO:0000313|EMBL:EMR86455.1};
OS Botryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=1290391 {ECO:0000313|EMBL:EMR86455.1, ECO:0000313|Proteomes:UP000012045};
RN [1] {ECO:0000313|Proteomes:UP000012045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BcDW1 {ECO:0000313|Proteomes:UP000012045};
RX PubMed=23704180; DOI=10.1128/genomea.00252-13;
RA Blanco-Ulate B., Allen G., Powell A.L., Cantu D.;
RT "Draft genome sequence of Botrytis cinerea BcDW1, inoculum for noble rot of
RT grape berries.";
RL Genome Announc. 1:E0025213-E0025213(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; KB707857; EMR86455.1; -; Genomic_DNA.
DR AlphaFoldDB; M7TYS4; -.
DR STRING; 1290391.M7TYS4; -.
DR HOGENOM; CLU_013399_0_1_1; -.
DR Proteomes; UP000012045; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EMR86455.1};
KW Transferase {ECO:0000313|EMBL:EMR86455.1}.
FT DOMAIN 141..280
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 521 AA; 57326 MW; 70EC2EEF152CB4C3 CRC64;
MASSMDSNHP FIDTMGITSD EYVREQAFVT DGTLTVGRNA SLTLGTDSLI VLDEAFEKES
ATCCGFWTFA SSSANTRPIP FYNVLWAEIS DTKELAIRYA APTSKTRVQA TELKYAIESN
STEEVEKWIA KLLDRSYGES QQTKRAKVLV NPHSGKGKAQ KYYDRDVEPL LKAANCSIDM
VKTKFQGDAV TIVEDMDVEA YDMVVCCSGD GLAHEVFNGL GKRHDAKKAL SKIAVTHVPC
GSGNAMSMNL NGTASASLAT LAIIKGIPTP LDLMSITQGE TRTISFLSQS VGIVAEADLA
TEHLRWMGSA RFTYGFLERL IGQAIYPCDI AVKVAIEDKP SIKDYYRKEM SNREPASERR
GYKHLLDDDA SASSGTDDGL PPLRYGTVSD KLPEGWEMVP YDKLGNFYCG NMAYMASDAN
FFSAALPSDG YMDLVCINGD ISRLSAIKMM LSVESGKLFD IPDVWYRKIL GYRIIPKQKG
DGYISIDGER VPFQPFQAEV HKGLGTVLSK TGHMYEWHGP I
//
