ID   M7W565_ENTHI            Unreviewed;       509 AA.
AC   M7W565;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   22-FEB-2023, entry version 26.
DE   SubName: Full=RhoGAP domain containing protein {ECO:0000313|EMBL:EMS12815.1};
GN   ORFNames=KM1_257980 {ECO:0000313|EMBL:EMS12815.1};
OS   Entamoeba histolytica HM-3:IMSS.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885315 {ECO:0000313|EMBL:EMS12815.1, ECO:0000313|Proteomes:UP000030780};
RN   [1] {ECO:0000313|EMBL:EMS12815.1, ECO:0000313|Proteomes:UP000030780}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HM-3:IMSS {ECO:0000313|EMBL:EMS12815.1,
RC   ECO:0000313|Proteomes:UP000030780};
RA   Inman J., Zafar N., Lorenzi H., Caler E.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB638387; EMS12815.1; -; Genomic_DNA.
DR   AlphaFoldDB; M7W565; -.
DR   EnsemblProtists; EMS12815; EMS12815; KM1_257980.
DR   VEuPathDB; AmoebaDB:KM1_257980; -.
DR   Proteomes; UP000030780; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23179:SF3; RHO GTPASE ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
FT   DOMAIN          27..226
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          393..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  59573 MW;  7DA624F65ADB81A5 CRC64;
     MKLKNNFKKF KNILINKQEE VIPYTGRTIK EILNDEKREP NQLPKAVEKM FHCMYEKGCY
     CKGIFRESQN ASIRKVEEIY MRMSVTNFED IPVDVIANVL KKFLRNLPVH IIDNEITQQI
     FFEWSKINKN ESIPELKIIQ TIQNILSLLP IEHQTIFKEL MKLSYKIISF SDLNSMNSKN
     LSICLSTNLM TLNEPEQISN TYDFTNDYTI CIDFISFCIS NYPLIFPNDV DEKLNKRRTY
     LFSSEQQSKL FSEQNIRSQR KKTSKLTDKL FKPNVVDGPK KIDVFDRITK KQQINQQQNQ
     LNSQKLIIDK SFPSKDDQST ISLSQNLHQN FNTTSPKDII TTRSSQYDSL NSNKIQLLKQ
     PRSTFDFVEL QNQQKLSKTT PIIALVNLPD IQESQTKSQD DGTTDNEPID ISFKNPELSF
     NSIDKMIFED KTDGNENNNQ NEFIEITKKA LDDEKKIHQE EMKKIEKERR LEELPPINTT
     NKNEQHNSLK FTYNEAIGTY TKSNPIFKD
//