ID M7WI34_RHOT1 Unreviewed; 1078 AA.
AC M7WI34;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=DUF221 domain containing protein {ECO:0000313|EMBL:EMS20147.1};
GN ORFNames=RHTO_03681 {ECO:0000313|EMBL:EMS20147.1};
OS Rhodotorula toruloides (strain NP11) (Yeast) (Rhodosporidium toruloides).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=1130832 {ECO:0000313|EMBL:EMS20147.1, ECO:0000313|Proteomes:UP000016926};
RN [1] {ECO:0000313|EMBL:EMS20147.1, ECO:0000313|Proteomes:UP000016926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NP11 {ECO:0000313|EMBL:EMS20147.1,
RC ECO:0000313|Proteomes:UP000016926};
RX PubMed=23047670; DOI=10.1038/ncomms2112;
RA Zhu Z., Zhang S., Liu H., Shen H., Lin X., Yang F., Zhou Y.J., Jin G.,
RA Ye M., Zou H., Zou H., Zhao Z.K.;
RT "A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.";
RL Nat. Commun. 3:1112-1112(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KB722663; EMS20147.1; -; Genomic_DNA.
DR RefSeq; XP_016271266.1; XM_016417350.1.
DR AlphaFoldDB; M7WI34; -.
DR GeneID; 27367694; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_009187_0_0_1; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000016926; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..177
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 201..363
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 375..655
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 861..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1078 AA; 119694 MW; CAF42F777B72A5BC CRC64;
MSDAQEATNA IFDAYESRLT RIGGPAVGIQ LALMVGVGLA AIIGFSVLRP NNSVVYQPKL
KYAADDKRPP KIGKGIFDWV RPVLTLKEQE MMALMGLDSV AYLRFLRMCR NMFICIAALT
CAVLIPINVV YNLRYVKEDN RNYLLILTMS KVKGNWLWAH VVATYVLTFM AFFFIWTNYD
AIVRLRWQWF RSPAYQDMLY ARSLMITQVN KKFQTDAGLA GLLASLNIPY PTSAVHIGRR
FGALPALIKK HNEAVEELEH VLTTYFKNPD RLPTQRPVKR IGGHMGLGGQ KSTTLPRRSS
VLSSASMRVA RAQIHERKAE NYGFASFESV PYAHIVAKTL RGKRRHGAHF DLAPQPKDLI
WDNLQMTDAA RTKNKFFGGI LLVLLCGFYT IPLVAVALLA NLAALSAYVG FINTWVSDYP
YLFSAFVGIV PPILTFLLQM ILPMIIRWIA SLQGATTHSQ SDRIVTARYS AFLFITQFII
FSLLGVIVQV VSQIVIQIQG HASASKIWDY LQTVPDKLQN TYMIQSTYWL TVFPLRGASA
CFDLAQIISL LVVWFKTRMF GRTPREIREA TKPPYFDFPV YYSNHLLVVA VAMVYAPIAP
LVGLFGAGVF AVSYYVYKYQ NLYVSVPRTE TGGRLWNVVV NRVLTALILM HIFMAVSIGL
QTNWFYAIAL APPAVCVLIF KIILDRKFID RFRWYIPGEV EMAEVHMHRA DARKNRLEKR
FGHDALSEPL WTPMLHKNVQ HLLPTIYNGR IEQGETKVGG KTVEQNVAGG LTFAMMEAHD
LTVDRAAYLR EREEDEMTIS TAFNNRAHRP GAPSVAGTDV DDYFAGRHAE YLKHGAAMSR
SGTPFNPGTP EELPAELQRM PTYDDQTPGS FFGMDGRTTP NASTDNLIQH AQPYQYPPSY
SSPDRSLPHH ARGMSGSPRI GGPPVGHRTN ASQTSFSSLS GAGAYEPGMQ QAHPLDLAQY
GRQGPPPPVG MARGPGARSA SVDSYAGQWQ PQHTAARSQQ SIDFAYGGAA PRGDPRRMSG
PYGGAGGPQE RLAQGVSAAP AAYGAAAYAD FGSGGAPRYA PLNPDGSEST EYLPQRRR
//
