ID M7WXU3_ENTHI Unreviewed; 1190 AA.
AC M7WXU3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=CH domain containing protein {ECO:0000313|EMBL:EMS16209.1};
GN ORFNames=KM1_194910 {ECO:0000313|EMBL:EMS16209.1};
OS Entamoeba histolytica HM-3:IMSS.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885315 {ECO:0000313|EMBL:EMS16209.1, ECO:0000313|Proteomes:UP000030780};
RN [1] {ECO:0000313|EMBL:EMS16209.1, ECO:0000313|Proteomes:UP000030780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HM-3:IMSS {ECO:0000313|EMBL:EMS16209.1,
RC ECO:0000313|Proteomes:UP000030780};
RA Inman J., Zafar N., Lorenzi H., Caler E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB637480; EMS16209.1; -; Genomic_DNA.
DR AlphaFoldDB; M7WXU3; -.
DR SMR; M7WXU3; -.
DR EnsemblProtists; EMS16209; EMS16209; KM1_194910.
DR VEuPathDB; AmoebaDB:KM1_194910; -.
DR Proteomes; UP000030780; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00030; C2; 1.
DR CDD; cd08368; LIM; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR23167:SF46; ALPHA ACTININ 3; 1.
DR PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00412; LIM; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00132; LIM; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 1..106
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 183..241
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 775..890
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 957..1060
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 113..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1190 AA; 139571 MW; D5ADFA80950403E5 CRC64;
MQGTQALLQW CKQNTAGYKD VNVTNFHYSW KNGLAFCALI HSFHPEAIDF NSLSKDNMEK
NLELAFSTAE KLGVPRLLDV EDFVLLEKPE QFSIITYLGV MYQMFQLKGG SVAEENKRVE
EEKKKEENIK KPVMTAQPYS STSKPPPRPI NRNNQPLSKS SGGTQTTPVI PKKKVTTQEQ
RLEVCVKCGQ TLSGNVLEAL GKKYHQQCFG CTTCSRKLGA SFVTVDNQPY CETCGKKIWV
QKQAKKKAEE QQKLSSQEEE KKVIEAQKAL EEKQKKEKEE FERKQKEEKE KREKEMAEKK
RREDERLAAL EKQKKERKER EEKLKREREE RLKKEQEEKD KKIQEMKEKQ AVLSKAPPSH
IVSTKTEPKT VVTSQNKNTG QEPEWKRKQR EAEEKKKEMQ DKLKAIKQKR LEEVKKKNQI
TSEKSKTASL SSKQKEPEEI ETKKQELDDQ AKKIEEEKQR KEKELKLQQE EEKKKREIEK
TKQEEEKKKR DEEFKQQKER EENLKRLEEN ERKIKEEEKK KTEEEKKEKD VKEFKSKQVT
IEEDNSNNKE ITSQQEEEQI KQANISKTKN VSIKQEEKQI EEERQIEEER QIEEEKQTKE
KELLQLEEKQ KKEREEFEQK QLQEKNNLRK TISKKSNDIK DLPLTEMSNT QTLKRDDLTQ
YVLRVNVLML KSNKEIKRPL FKLSLETKQS NIQSTRVNKI NDNIGSSLFF KEITSVTNLT
IKVVEESTKT VYQEIIVPLN NLELNNVTPV TSQLYDSQYP AELLYTLQLI TSIEGMRQTA
ISVQDLRSDK LQEGVFSLRI NSIKDLPPMN GIKEAYCIVK VGKQNPVQTK SIIPSVPVWN
HFMAFDCNHD DQVRIEIFGK KKSLLKQTII PFGQVSISLK GIKGIQERWL TILPQGTEQV
QGQLSVSLYY QDNSVEMEGA DPTLLSNLST KFEKLAEKTQ GDLPEGVEID PTDVKNWDGK
AGYLFMRSQK TGKMKRRFFY LLQFNRELIY YKQQQVRFNK QREGSINEVP KVIDLAFAEI
RTIPNSTKFV IILPQRQYIL DATTKQEKDS WISRISDELK SIKEYASKEI NMSLEKLGRN
TYEAQKGIIK MLRDKKFQTV HIELRSGFIF IYEMIKSSNM KLIDKLSLYK CYMSEYEPDK
CPNSIKIEDQ YKKKAFIFQL DCFEDMHFWL NGMKFQQIFI EEAIDNIVLI
//
