ID   M7X214_ENTHI            Unreviewed;      1054 AA.
AC   M7X214;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   08-NOV-2023, entry version 35.
DE   SubName: Full=Bromodomain containing protein {ECO:0000313|EMBL:EMS14033.1};
GN   ORFNames=KM1_166100 {ECO:0000313|EMBL:EMS14033.1};
OS   Entamoeba histolytica HM-3:IMSS.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885315 {ECO:0000313|EMBL:EMS14033.1, ECO:0000313|Proteomes:UP000030780};
RN   [1] {ECO:0000313|EMBL:EMS14033.1, ECO:0000313|Proteomes:UP000030780}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HM-3:IMSS {ECO:0000313|EMBL:EMS14033.1,
RC   ECO:0000313|Proteomes:UP000030780};
RA   Inman J., Zafar N., Lorenzi H., Caler E.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB638044; EMS14033.1; -; Genomic_DNA.
DR   AlphaFoldDB; M7X214; -.
DR   EnsemblProtists; EMS14033; EMS14033; KM1_166100.
DR   VEuPathDB; AmoebaDB:KM1_166100; -.
DR   Proteomes; UP000030780; Unassembled WGS sequence.
DR   CDD; cd05529; Bromo_WDR9_I_like; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR16266:SF17; BRWD3; 1.
DR   PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          1..42
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          43..84
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          736..807
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   REGION          470..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          847..886
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          903..1054
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        485..501
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        857..886
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        939..966
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1009..1024
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1054 AA;  122964 MW;  8A811D707D079CA2 CRC64;
     MIGHTKKITQ QLFDMDREMM ITASEDGLIK LWNLIDGHLI ATLRGHSKGV EDIDISFDHK
     YLASCGADGR CIIWDLENKK IEKSFFVSHK KTTMVTFFPK TYGFIVMEKD NLGHVFTPTL
     EFLASIDCFW ETKKTFDYGC FNTSGDMFTS TCGDIILFSF KDPVPERVNA LYKSKDSMTF
     VNKVRDKDLF ICGSSQKLVI CDFTENVKIL YLKQQKNMTS NCYVLEFNGG EIKERIETSK
     ITNDLKFEDG QTIIWDLING LHPILFFTRD DYHDKDLRSL LLTDLRFSPD GSYLSVADDL
     GTFSLFGIGS EGKSSFRWTP PQQFFQSDYN KLLYDGAGNC IDEKFKVAPH LVPRGSVCDF
     TFIPYSSIQQ ILNTNNKLLL QCTENRFTPE TYSFRDNPEE AIIPRISITT EPNEQNPMLE
     DTPGEADDAV FDVDEDIDIT QQHLTRNAAS RMGIVIPDNG TEEVPAVPIV DDGSLEVNES
     SSLESSSLDE EEEELFEELE SSQAEEKEKK PTKRGQRQSI NSVVIEETYT ELLKEIYTSY
     PHWINKVVGE YDMTCPKKRK VYFPNIGDHV YYVPRFHEEY LKDISTNITG TDNLHYIGTE
     GWISCQITFM KIYYDDIQNE VFVSVDLKVE KEDVIINNIV FTQSRNQFIF LKEFIDYNVQ
     YIEEQSHKRV NYGGSSYRVD FDNSIFMKYK GIKLVSSNGS IDVSINEIDS DYTEHRSDDF
     ADEVREILIN KLREIVDNED YQIFKTPVDI RMYPNYIPTC PFPIDFNLIL QRLINDNYYR
     TYDQVEWEIF KLIRNAVTYN GPNSPIGECA IEIAEELKPT LETCRTVVNT DLLVDLNTQL
     ESFKEITIPN SSTKQRKTRK GNTETRQQEV KEVKEPSQES EEIQVMPKRN LRHNFIATDY
     ELSLKEDNEE EEEEIEPKPR SKRRKTKNTS KQMNEEESQI YEEEQEFEQR LEEQLQEEED
     SEEEDNPDTF IRPRRRRAKK ITMPTRKRKQ TKIEEKEDDF EEYFDTDDGD DYPVKRKYTT
     QEEQEDDESL KDENTELLEP SRFRRKTRNM NSSS
//