ID M7X216_ENTHI Unreviewed; 460 AA.
AC M7X216;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 03-MAY-2023, entry version 44.
DE SubName: Full=Rho/RAC guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:EMS17699.1};
GN ORFNames=KM1_040400 {ECO:0000313|EMBL:EMS17699.1};
OS Entamoeba histolytica HM-3:IMSS.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885315 {ECO:0000313|EMBL:EMS17699.1, ECO:0000313|Proteomes:UP000030780};
RN [1] {ECO:0000313|EMBL:EMS17699.1, ECO:0000313|Proteomes:UP000030780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HM-3:IMSS {ECO:0000313|EMBL:EMS17699.1,
RC ECO:0000313|Proteomes:UP000030780};
RA Inman J., Zafar N., Lorenzi H., Caler E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; KB637127; EMS17699.1; -; Genomic_DNA.
DR AlphaFoldDB; M7X216; -.
DR EnsemblProtists; EMS17699; EMS17699; KM1_040400.
DR VEuPathDB; AmoebaDB:KM1_040400; -.
DR Proteomes; UP000030780; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00065; FYVE_like_SF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF263; GRFA PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 44..230
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 262..352
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 376..434
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
SQ SEQUENCE 460 AA; 53599 MW; 51BAA4B2AAB908A0 CRC64;
MTDLPDERCS NCFHSIEAHT LPVELFNNIK CDKPTILTTP REVYRKKIAM ELLTTERTYV
RMLMTCLRCY ADPLQSCEPP LLPPTLYKSI FLFYRDIVRV NLVFLQSLED LVEKNQLVSG
LSSVFLGTLP YLRVYRMFVG NNSVGLQAVE QAEHMKDVVK LLHHCSKYGY EGETVQPLRS
YLILPIQRIP RYNLLLSDFL KHTDRNDPLF EETTALVGSL KSLAKEINDE VKLQDNRRKL
LAIKKKFCEG PYHLTLVEAH RYIMREGILF KLSKTKPKKR YFYLFNDILV YGRMQLQLFY
PNLYLRLNSV HIEDGLQPNT FNLLSPFKSF TVICSSIEER NTWANDLKSA IQKESDKKFS
KNIDTVGFDA PLYQPFNEAT LCFICKRKFG IFCFKYHCER CGFVVCDSCS KNRKIVPPNP
VPQRICNFCV RSADRNIEVF KGLRKRSKQE RARLALALLE
//
