ID M7XE63_RHOT1 Unreviewed; 1566 AA.
AC M7XE63;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Rho guanyl-nucleotide exchange factor {ECO:0000313|EMBL:EMS22109.1};
GN ORFNames=RHTO_00863 {ECO:0000313|EMBL:EMS22109.1};
OS Rhodotorula toruloides (strain NP11) (Yeast) (Rhodosporidium toruloides).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=1130832 {ECO:0000313|EMBL:EMS22109.1, ECO:0000313|Proteomes:UP000016926};
RN [1] {ECO:0000313|EMBL:EMS22109.1, ECO:0000313|Proteomes:UP000016926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NP11 {ECO:0000313|EMBL:EMS22109.1,
RC ECO:0000313|Proteomes:UP000016926};
RX PubMed=23047670; DOI=10.1038/ncomms2112;
RA Zhu Z., Zhang S., Liu H., Shen H., Lin X., Yang F., Zhou Y.J., Jin G.,
RA Ye M., Zou H., Zou H., Zhao Z.K.;
RT "A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.";
RL Nat. Commun. 3:1112-1112(2012).
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DR EMBL; KB722652; EMS22109.1; -; Genomic_DNA.
DR RefSeq; XP_016273228.1; XM_016414547.1.
DR GeneID; 27364876; -.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG4424; Eukaryota.
DR HOGENOM; CLU_245676_0_0_1; -.
DR OrthoDB; 53554at2759; -.
DR Proteomes; UP000016926; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR12673:SF270; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
FT DOMAIN 1123..1378
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..562
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..820
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1566 AA; 166891 MW; FA3E5978FDE615E5 CRC64;
MSGSDTHLSL FNTPTSPLSL ANPAQRPPVD GESSKLMKET GASGGGRTRS DGERDAQDRR
FGHDGLSHGG TGGLRAVAGE HSLPQPLDSV STGHQRRDAL PRARPHAEGL HEREGSVLDR
RTSELLEQTG LADLLDDSLV HPNNRPTSTT LSTSRSTSSV SSKYYAASAE PPTSTSARPV
PRSPPRSSRT LSSAALAALA DSPARPPRPP KSHARPPSRA SIASSADSGA ATEGGGGTPD
AGHVDSGNPS AIQPFDSPSL EEAGGLAFPR LRAGTASTDR TPALSTASSA SARNSAVFYS
SLEEEVEDDG EPWNAATPAT TVDYSSPSFP SSDLAAVDPH AASPALKRTR PVEPLQLHLA
PPMSPSSTTN TLKGLGLNFF TASAASSSST TVSSPLSATV PPMLNEDDLD RELERLSQYA
KSLPSPLPGV FARSDPSSAG VADWTAQDED AAESAVEEEK TLVVDGLRTA DPVPPVPPLP
PHFPSTHPHP ATHSFGPSAG TLLASPSRRP ALLNLPNYRP APSTRDYLSP APGLGIADET
DFVSTTDAGE DDDDEDDEGD DSFGFQIDTR VPPPNAFGRN EKATSLWNED VAWRGSPAVS
TAGAGQAERE REDVVDWSDS PVEKRELPRE TTHLILARSK TPFQIAPLLT NAVPMLTHGL
VVLDIRECGL SEIPSAIASC CFLQELDVSG NSLAMSTLPS FLGTLPALNV LLADECNLAS
LPNSLSQLTR LHTLSLRRNR LRMLPSWLCR LTALETFLID ENPFVWEVQN LVRPLLVDAG
VEREDGARTP LSHAPSPIPP ASFRSTPSPL PPPPQFADSR PPSPAFARSR SNSSIPAWSS
SVAPSPALSR ASSRGDLSES LGSLMLREDA SPLPTPSPAF SASGETNAEP VDADKKEKRK
WGQRLLKKVS AGRLRSSSSA SKRPGALDAD ARTFSQPVTR GEESEAEKQV PSSGGMFGSL
GRKTIKRSKG PAQAPRSAPP VNKRKSFLLL DAFSPAPASP GTPALNDHAS ALRNVLAYLR
DLDDLSPDVL LPAIPLDNPS PHLRHSPSLG ALTPGGSPRP ASPASMRRAQ STRRLPSNGS
VRRGSSAHFS QFLDDTPDPS DRSSFILSMP DLAASKVNDD PAKRDAILKE IVATEQSYLR
GLEELCGIYV ASASVPVSSS MNGGKKDTVV PTAERRAVFG NIEAIRDFHR KILLPDLLAA
VRTGGDSTTV AEKVGEVFVD HASFMKIYSG YINGFDDALA RIQSWGKNSS NRPSAGAVSP
ALSSPALASS TTFDATASIA QTLSSSQRKR IRSWLKRCRA HPSHSQISLE SYLLLPIQRI
PRYRLLLESL SSCTPAPIDS TADVLASSLP PDSPFAPHPI IAQAVAEMDA VATTLNESKR
ENEGRAQLVM WQNRLVTKFK SPLVQPHRTL LRSGYITLVR SVKRSTTQME QQPPSPYRTT
SGRLLEQPEP VATLFQDTKQ VELIALLCTD LLVLCRRPPP PFDADPNSPV ELYTVLRLNS
ARGTPFGSSG RSEPPACVFG ADDLLRVKIG DKAICYFRCI ADNASKNRKE ASAWANAINV
QWEVNT
//
