ID   M8AQU2_AEGTA            Unreviewed;       598 AA.
AC   M8AQU2;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Aspartic proteinase nepenthesin-2 {ECO:0000313|EnsemblPlants:EMT04115};
OS   Aegilops tauschii (Tausch's goatgrass) (Aegilops squarrosa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX   NCBI_TaxID=37682 {ECO:0000313|EnsemblPlants:EMT04115};
RN   [1] {ECO:0000313|EnsemblPlants:EMT04115}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   AlphaFoldDB; M8AQU2; -.
DR   EnsemblPlants; EMT04115; EMT04115; F775_22300.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.70.10; Acid Proteases; 4.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR032799; TAXi_C.
DR   InterPro; IPR032861; TAXi_N.
DR   PANTHER; PTHR13683; ASPARTYL PROTEASES; 1.
DR   PANTHER; PTHR13683:SF808; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14541; TAXi_C; 2.
DR   Pfam; PF14543; TAXi_N; 2.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 2.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454}.
FT   ACT_SITE        212
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        371
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
SQ   SEQUENCE   598 AA;  64152 MW;  B67BF11E1BDC2A8E CRC64;
     MASAGRSLLY GLLVLVLALL CVGALAAPPK RYLSVSLDQV VASKARAQCY DPSSFSGETS
     GNKFAIHPSC SAAEQAGRHR NIASHDRARL STIRQRSYPS AMPPMSMPPI PPFIFPPSPT
     PGSAPAKGMP PMLPAIAFPP MFFPPNPAPA EGMPPVPAVA FPPIYFPPAP APAEGPSVTI
     PDIPGTSGYN ISEFIVVVGF GTPSQPSALL FDTGSDLSWV QCQPCTGHCY QQNGPLFDPT
     KSSTYDVETL TFSSSRKFSS FPFGCGTTNL GDFGSVDGLL GLGRGQLSLA SQTASSFDGT
     FSYCLPSHNM TRPGFLSIGA APDTGKVQYT AMIKKPQYPS FYFVELASIN IGGYVLPVPP
     SVFTSKGTLL DSGTTLTYIP SKAYALLRDR FKFTMKGYKP APPSEELDTC YDFSGHNAIF
     IPGVSFKFSD GAVFELDFFG IMMFPDDAQP AYGCLAFAAG DDDSFSIIGN TQQRSAEAFT
     YIPAQAYTLL RDRFKFTMKG YNPAPPFQDL DTCYDFSGQS VIFQPGMSFK FSDGAVFDID
     IFGVMIYPYV DHPAIGCFAF ASSDPTDQFS IIGNTQQRSA EVIYDVVAEK IGFVPLSC
//