ID   M8BUH1_AEGTA            Unreviewed;       532 AA.
AC   M8BUH1;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Vacuolar-processing enzyme {ECO:0000313|EnsemblPlants:EMT10444};
OS   Aegilops tauschii (Tausch's goatgrass) (Aegilops squarrosa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Aegilops.
OX   NCBI_TaxID=37682 {ECO:0000313|EnsemblPlants:EMT10444};
RN   [1] {ECO:0000313|EnsemblPlants:EMT10444}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C13 family.
CC       {ECO:0000256|ARBA:ARBA00009941}.
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DR   AlphaFoldDB; M8BUH1; -.
DR   EnsemblPlants; EMT10444; EMT10444; F775_29763.
DR   ExpressionAtlas; M8BUH1; baseline.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0051603; P:proteolysis involved in protein catabolic process; IEA:InterPro.
DR   CDD; cd21115; legumain_C; 1.
DR   Gene3D; 1.10.132.130; -; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR043577; AE.
DR   InterPro; IPR048501; Legum_prodom.
DR   InterPro; IPR046427; Legumain_prodom_sf.
DR   InterPro; IPR001096; Peptidase_C13.
DR   PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR12000:SF42; LEGUMAIN; 1.
DR   Pfam; PF20985; Legum_prodom; 1.
DR   Pfam; PF01650; Peptidase_C13; 2.
DR   PIRSF; PIRSF500139; AE; 2.
DR   PIRSF; PIRSF019663; Legumain; 2.
DR   PRINTS; PR00776; HEMOGLOBNASE.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          419..515
FT                   /note="Legumain prodomain"
FT                   /evidence="ECO:0000259|Pfam:PF20985"
FT   ACT_SITE        175
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT   ACT_SITE        217
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ   SEQUENCE   532 AA;  58105 MW;  919B2E3560578C7E CRC64;
     MAMASFRPLP LALLLAACLS AFVLAVAHAR TPGLDPTIRL PSQRAAGQED DDSVGTRWAV
     LIAGSNGYYN YRHQADICHA YQIMKKGGLK DENIIVFMYN DIAHNPENPR PGVIINHPQG
     GDVYAGVPKD YTGKEVNVKN FFAVLLGNKT AVSGGSGKVV DSGPNDHIFV FYSDHGGPGV
     LGMPTYPYLY GDDLVDVLKK KHAAGTYKSL VFYLEACESG SIFEGLLPND IGVYATTASN
     AEESSWGTYC PGEYPSPPPE YDTCLGDLYS ISWMEDRANL MAMELGASFA VNAPCRNSCS
     CCTQPYSYEI ATEHHLDVHN LRTESLKQQY NLVKKRTAAQ DSYSYGSHVM QYGSLDLNAE
     HLFSYIGSNP ANENTTFVED NALPSFSRAV NQRDADLVYF WQKYRKLAES SPEKNDARKQ
     LLEMMGHRSH IDNSVELIGN LLFGSAGGPM VLKAVRPAGE PLVDDWSCLK STVRTFESQC
     GSLAQYGMKH MRSFANICNA GIVPEAMAKV AAQACTSIPT NPWSATHKGF SA
//