ID M9MSK6_DROME Unreviewed; 4352 AA.
AC M9MSK6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Ankyrin 2, isoform Q {ECO:0000313|EMBL:ADV37504.1};
GN Name=Ank2 {ECO:0000313|EMBL:ADV37504.1,
GN ECO:0000313|FlyBase:FBgn0261788};
GN Synonyms=ank2 {ECO:0000313|EMBL:ADV37504.1}, ank2-L
GN {ECO:0000313|EMBL:ADV37504.1}, CG18025 {ECO:0000313|EMBL:ADV37504.1},
GN CG18227 {ECO:0000313|EMBL:ADV37504.1}, CG18768
GN {ECO:0000313|EMBL:ADV37504.1}, CG32373 {ECO:0000313|EMBL:ADV37504.1},
GN CG32375 {ECO:0000313|EMBL:ADV37504.1}, CG32377
GN {ECO:0000313|EMBL:ADV37504.1}, CG34121 {ECO:0000313|EMBL:ADV37504.1},
GN CG34158 {ECO:0000313|EMBL:ADV37504.1}, CG34416
GN {ECO:0000313|EMBL:ADV37504.1}, CG7462 {ECO:0000313|EMBL:ADV37504.1},
GN CG7493 {ECO:0000313|EMBL:ADV37504.1}, DAnk2
GN {ECO:0000313|EMBL:ADV37504.1}, Dank2 {ECO:0000313|EMBL:ADV37504.1},
GN dank2 {ECO:0000313|EMBL:ADV37504.1}, Dmel\CG42734
GN {ECO:0000313|EMBL:ADV37504.1}, ESTS:149B10S
GN {ECO:0000313|EMBL:ADV37504.1}, SP2523 {ECO:0000313|EMBL:ADV37504.1},
GN sp2523 {ECO:0000313|EMBL:ADV37504.1};
GN ORFNames=CG42734 {ECO:0000313|EMBL:ADV37504.1,
GN ECO:0000313|FlyBase:FBgn0261788}, Dmel_CG42734
GN {ECO:0000313|EMBL:ADV37504.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ADV37504.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:ADV37504.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:ADV37504.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:ADV37504.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:ADV37504.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:ADV37504.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AE014296; ADV37504.1; -; Genomic_DNA.
DR RefSeq; NP_001189067.1; NM_001202138.1.
DR SMR; M9MSK6; -.
DR DNASU; 38863; -.
DR EnsemblMetazoa; FBtr0303112; FBpp0292231; FBgn0261788.
DR GeneID; 38863; -.
DR AGR; FB:FBgn0261788; -.
DR CTD; 287; -.
DR FlyBase; FBgn0261788; Ank2.
DR VEuPathDB; VectorBase:FBgn0261788; -.
DR GeneTree; ENSGT00940000167243; -.
DR OrthoDB; 3139942at2759; -.
DR BioGRID-ORCS; 38863; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 38863; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0261788; Expressed in brain and 24 other cell types or tissues.
DR ExpressionAtlas; M9MSK6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031594; C:neuromuscular junction; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; HDA:FlyBase.
DR GO; GO:0042734; C:presynaptic membrane; IDA:FlyBase.
DR GO; GO:0036062; C:presynaptic periactive zone; IDA:FlyBase.
DR GO; GO:0043195; C:terminal bouton; IDA:FlyBase.
DR GO; GO:0048675; P:axon extension; IMP:FlyBase.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:FlyBase.
DR GO; GO:1900074; P:negative regulation of neuromuscular synaptic transmission; IMP:FlyBase.
DR GO; GO:0007528; P:neuromuscular junction development; IMP:FlyBase.
DR GO; GO:0070050; P:neuron cellular homeostasis; IGI:FlyBase.
DR GO; GO:0045887; P:positive regulation of synaptic assembly at neuromuscular junction; IMP:FlyBase.
DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase.
DR GO; GO:0007614; P:short-term memory; IMP:FlyBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 24.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:M9MSK6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 50..82
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 83..115
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 116..148
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 149..171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 211..243
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 244..276
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 277..309
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 310..342
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 343..375
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 376..408
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 409..441
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 442..474
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 475..507
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 508..540
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 541..573
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 574..606
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 607..639
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 640..672
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 673..705
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 706..738
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 739..771
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 966..1123
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1125..1272
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1457..1539
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 900..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1579..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1694..1716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1890..1930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1965..1994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2120..2164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2180..2199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2378..2400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2581..2618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2688..2787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2840..2870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2945..3107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3276..3337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3396..3419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3541..3670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3742..3768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3782..3806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3861..3905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4124..4157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4314..4352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1694..1713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2120..2155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2581..2603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2604..2618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2693..2712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2719..2737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2847..2868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2950..2975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2976..2996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3032..3050
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3068..3098
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3590..3642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3650..3666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3782..3800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3879..3903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4127..4150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4316..4332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4333..4352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4352 AA; 478689 MW; 8DF8DE699BAA8D5D CRC64;
METLKKRFPS LQSLGGDGNT SFLRAARAGN LERVLEHLKN NIDINTSNAN GLNALHLASK
DGHIHVVSEL LRRGAIVDSA TKKGNTALHI ASLAGQEEVV KLLLEHNASV NVQSQNGFTP
LYMAAQENHD AVVRLLLSNG ANQSLATEDG FTPLAVAMQQ GHDKVVAVLL ESDTRGKVRL
PALHIAAKKD DVKAATLLLD NDHNPDVTSK SGFTPLHIAS HYGNQNIANL LIQKGADVNY
SAKHNISPLH VAAKWGKTNM VSLLLEKGGN IEAKTRDGLT PLHCAARSGH EQVVDMLLER
GAPISAKTKN GLAPLHMAAQ GEHVDAARIL LYHRAPVDEV TVDYLTALHV AAHCGHVRVA
KLLLDRNADA NARALNGFTP LHIACKKNRL KVVELLLRHG ASISATTESG LTPLHVAAFM
GCMNIVIYLL QHDASPDVPT VRGETPLHLA ARANQTDIIR ILLRNGAQVD ARAREQQTPL
HIASRLGNVD IVMLLLQHGA QVDATTKDMY TALHIAAKEG QDEVAAVLIE NGAALDAATK
KGFTPLHLTA KYGHIKVAQL LLQKEADVDA QGKNGVTPLH VACHYNNQQV ALLLLEKGAS
PHATAKNGHT PLHIAARKNQ MDIATTLLEY GALANAESKA GFTPLHLSSQ EGHAEISNLL
IEHKAAVNHP AKNGLTPMHL CAQEDNVNVA EILEKNGANI DMATKAGYTP LHVASHFGQA
NMVRFLLQNG ANVDAATSIG YTPLHQTAQQ GHCHIVNLLL EHKANANAQT VNGQTPLHIA
RKLGYISVLD SLKTITKEDE TAAAPSQAEE KYRVVAPEAM HESFMSDSEE EGGDTNWQLD
AGYEYGFGPI YLPYYQGDKH YVSSEDNMLS DQPYRYLTVD EMKSLGDDSL PIDVTRDERM
DSNRMTQSAE YASGVPPTIG EEVISPHKTQ VYGSSPKATV DGVYIANGSG HDEPPHVGRK
LSWKSFLVSF LVDARGGAMR GCRHSGVRMI IPSRSTCQPT RVTCRYVKPQ RTMHPPQLME
GEALASRVLE LGPCSTKFIG PVVMEVPHFA SLRGKEREII ILRSDNGETW REHTIDNSEE
IIHDVLQQCF EPEEIAQLEE QAGNHVCRFV TYDFPQYFAV VSRIRQEVHA IGPEGGMVSS
TVVPQVQAVF PQGALTKKIK VGLQAQPVDP DLTAKLLGRG VAVSPIVTVE PRRRKFHKAI
TLSMPAPKAH SQGMINQYSG NTPTLRLLCS ITGGPSRAQW EDVTGSTPLT FVNDCVSFTT
TVSARFWLMD CRNISDATKM ATELYKEVIH VPFIAKFVVF AKKVEPFEAK LRVFCMTDDR
EDKTLEKHEL YTEVAKSRDV EVLEGKPQYI EMAGNLVPVT KSGDQLQVQF KAFRENRLPF
TVRVKDQHAD IVGRTLFMKE PKVAKGEPPQ QPICILNIVL PEAVIPDSTT AFSDRVTSAY
RTSMFSLSKH QNDHYIGDIR IVDLSNLLGK DWIQLAPEIG INGEEIDEII NQNTDSIARQ
AQSMIRLYKD KPNYDILSLE TALKNIGRDD IMKKCKSGRL SHSREFDEAD LMKNSESVEE
LVRRESKRIQ QINEREEVKY SAEEKEVEES ESDEEAAKRT VAERREKIVK RLSIERSIPA
STQKKEITRE ITEIKRKSLI EDKKAHHESE ILMQLPADNV IIKTTTVPDQ VIKMKMGKMD
STEVSKSEFD KELTHKFKTS GRSSEEEDQP SYPDQTDKIV QDISAAEKKE KDGVTFSRVT
TITRQEARDI TEDFLEIEKR SQLPATSTTA TVHEKFVEEI KEKTSPLASV PQETVKEVQQ
VISEVTEIAS KKVENIISSF ESSKSVDATT VLPTQPSVES TKVSETIKNL EDAKAVSAEQ
VKTVHVVESS SIEETIAEFE AKKVKYDFHG GEPKTQIPKF TRKPSDDSMK PTAAPRATVE
SETESVLETK AEKPISKIPV KTIPTEAQKV SEVDARKITQ DFLQGEKLAA EPKPSPAASK
IPKVEPRKSV DKQVDRESKI LDDVVASTAT IMTAGLGDEQ LKDQLVDHSE IIAKSETVAE
KVTELLDTFH KIEEKVTKSE KTSEISSKVE ELVKIEEKPL SQVQPKEDKV AEKVAEVIET
FHKIEEKITT ADARELTRDF LSMEQQNQLP SMPQAAEKPL ESSLTSTSAS EPESIVTVKP
SPPASKIPVV EPRKIVFDES TKPLIEPEPV KTTEKKPLNE RQLTADFLSM EQQTQLVSEP
AKSLVEEVMK SAEQMVEQPK QQKSLNERQL TEDFLLMEQQ TQLPSDIVKP TDKLIDGIES
AAPVGDEASP FHTPKLTTSV VTQEPQQLAS EYDSDTFGKQ ATIPLGDSKI DQGLIAPVSM
EPRKSLTDAE FCKSVGETIT KKMSVGVIEI SDELKKIESE IPHSQTPPPT PSDNKTDKQN
EEPELISLER DYLADTVTTL HTTTESTLER VSAITKIETL HERKVELSNL DTEKISHEIG
DVKVGGGDDD SDGDSGDFVA RIREEANILV DRVLEESVEI IESQGHQANG HEIAKLDYNS
ESENYAITCD DIGGVDVIKS PTIESMSGKS FDDNMSFTDE HIHLPLHAQN TSTTMTTTIT
TQFQQQQSQS AVSSTSAAKA SSRNQTEDES ETRARRIDHK IEKLSTDMDD VSARFDEAFE
MSVPEDEISA LQGDFSKLSW DESVSPTTNT MADMAQNQIT PDNDIQDLIA ETGGDLPNSS
ETDTTPVPPS KESESKTETE PTVVTNAFTT TSHDTPTPKP RVLKASSPVS EGTDSTTIPG
PVPKPEIPID ISFDANAPVP KPRAPIKHTE PFENLAALAE QSDSISLRSF ELTEDISKTD
EPSTELSIRS QLRDIVTTTT VSEDHTESFE PTSEISVDDA DTEKSEGAEK TTSFYIGESS
RNVIIKTSTR SASVTPQEEE AQGEIGIDAK DISLMKEVSV DSDEANDVFK EFITMKPEDP
IAMDSKITRQ GSETRNDILE FENADKDKTA EQKLSKVTTE ESLTTSTGSS GRAIIEIAPS
SSEDPDESSK EIPEIVNTIS EKAAASDNFE LPLEKSEWET SEKEIPTEGK PKVVHSPQQP
QEASMKSTLD RFHVDEILAE EQVTDEHSSS DHKSFKDQTP SELGSSTVPQ EYTFAVESED
ISSFIGIPEA SMQTSTLDST QPPEGLFDTT IKETLNKQAA MAHYAQDVFG RGERRDDHGS
LGFISTGTAE ELSSMEEHMA KEEQASLGFI STETAEDFSS MEDYYSEKLA IASVVADEVA
TEKSLTTSTF EELSSDQSMK PIDVVVHRLK TETSPDSINR WSIPDVDTSS SSESFHRSFD
KTQSRPLSSD LDNLVTTTGT GTSSDYQTAR EFTTTGRTEG TEYISAVSTL GSSSLDSQSE
TSANLASIDV SELSETLVAS SAEVDAFEAE EMSRLRDLRA DDEDSDESVE LPGTAGYPSI
EQQSLMKRSQ EMIFKPKTLD DEPLAVQVAQ IEEYPKPKEA ERTWGLAYPL EDSKVDSPRE
SEKGEDILLY HGDPRRSIDE SKLASSLDEG SILSVSMSST SNIDTVVENF DDIIGSAGSS
SLTGIEGFQY GHDESIPSAS VPEDATFMLE MESKEHSPQD SNASTPPGGE SKRRGHKRNE
SISGDALKNL DKEVALLGEG KESESESDTD PYESEYARQF RSPKERKSKK KKQAAAEMDH
SGELEKRPFT PSQLVAEVIV EDSITEELEA EAAMIEERRP SQNMQDYSNI PDIMVTEDIK
SPILEEETDE FPEKMLYKVR TEEELHKASD TSVYQKAKAE EKEQDFQRRV QEQYRQKLEE
LKRAEVGAEY DDRKAPDSPD SFEMVEQPDI SDEFVIIEEV AKEANEVDLG GQSIKIKPVK
YEQKHDEDVE KIIIKSAPAD PKLGSQLYKD DLNFEFEESP PTGASSSSEQ QEESDSSETA
AANKRWVEMQ LTDNQLRYPY DLAGAVLEDI KEEDGEFEVG SSRISSFKDS FSSTPEYDVA
ARRYHSRGEH DDVSMSSLQE FESLEQAISL ENRNRTHQGS TDSSNGSFTR RYVVRHSGSG
TAPGDDVSVS SLKDFEGLEN ACIEAHLIEI KAREEAALLS RSDESNKSNG SDKGATGNVV
VTKVTRTVTR TEVVPSSQVE SIEALLKQKL EREEGSVQGR VTDIGTTELD TKSKIDSQDS
EKDSIDSMEI SKSHDMMTSS IESFDISKDA TTRSDVDSLE IDKRHSRQES IESFGDEQLD
LMTKFVSGGG VTLGDGLTTT TTTTTTSTDA DGHEHTVTRV ITTITNVGGG IQELPMDESG
MSKDVSVDSL NMCVEQTTSS AGTTATYQTS AGNSQMSGSV TSCASSTLME DSFPGVGGMS
SSQMSASFWS HDESTVVEDE GRDLAKKPQQ GH
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