ID MCTS1_DANRE Reviewed; 181 AA.
AC Q7ZV34;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Malignant T-cell-amplified sequence 1;
DE Short=MCT-1;
GN Name=mcts1; ORFNames=zgc:56242;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role as translation enhancer and involved in cell
CC cycle regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The PUA RNA-binding domain is critical for cap binding, but not
CC sufficient for translation enhancer function. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MCTS1 family. {ECO:0000305}.
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DR EMBL; BC046019; AAH46019.1; -; mRNA.
DR RefSeq; NP_957365.1; NM_201071.1.
DR AlphaFoldDB; Q7ZV34; -.
DR SMR; Q7ZV34; -.
DR STRING; 7955.ENSDARP00000037227; -.
DR PaxDb; 7955-ENSDARP00000037227; -.
DR GeneID; 394046; -.
DR KEGG; dre:394046; -.
DR AGR; ZFIN:ZDB-GENE-040426-957; -.
DR CTD; 28985; -.
DR ZFIN; ZDB-GENE-040426-957; mcts1.
DR eggNOG; KOG2523; Eukaryota.
DR InParanoid; Q7ZV34; -.
DR OrthoDB; 5036262at2759; -.
DR PhylomeDB; Q7ZV34; -.
DR PRO; PR:Q7ZV34; -.
DR Proteomes; UP000000437; Chromosome 14.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR CDD; cd11609; MCT1_N; 1.
DR CDD; cd21155; PUA_MCTS-1-like; 1.
DR Gene3D; 3.10.400.20; -; 1.
DR InterPro; IPR016437; MCT-1/Tma20.
DR InterPro; IPR041366; Pre-PUA.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR004521; Uncharacterised_CHP00451.
DR NCBIfam; TIGR00451; unchar_dom_2; 1.
DR PANTHER; PTHR22798:SF0; MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1; 1.
DR PANTHER; PTHR22798; MCT-1 PROTEIN; 1.
DR Pfam; PF17832; Pre-PUA; 1.
DR Pfam; PF01472; PUA; 1.
DR PIRSF; PIRSF005067; Tma_RNA-bind_prd; 1.
DR SMART; SM00359; PUA; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS50890; PUA; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cytoplasm; Growth regulation; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..181
FT /note="Malignant T-cell-amplified sequence 1"
FT /id="PRO_0000344791"
FT DOMAIN 92..171
FT /note="PUA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
SQ SEQUENCE 181 AA; 20609 MW; 84940BAFE2929648 CRC64;
MFKKFDEKEN VSNCIQLKTS VIKGIKNQLL DQFPNIDDWL NQIMPKKDPV KIVRCHEHIE
ILTVNGELLF FRQREGPFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG
AKLYPAESDT VVAIMAEGKQ HALCVGVMKM SADDIEKVNM GIGIENVHYL NDGLWHMKTY
K
//
