ID   MMPLB_MYCLE             Reviewed;        1014 AA.
AC   O06079;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   27-MAR-2024, entry version 111.
DE   RecName: Full=Probable transport protein MmpL11 {ECO:0000305};
GN   Name=mmpL11; OrderedLocusNames=ML2617; ORFNames=MLCL622.16c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC32149.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Z95398; CAB08803.1; -; Genomic_DNA.
DR   EMBL; AL583926; CAC32149.1; ALT_INIT; Genomic_DNA.
DR   PIR; G87236; G87236.
DR   RefSeq; WP_041323530.1; NC_002677.1.
DR   AlphaFoldDB; O06079; -.
DR   SMR; O06079; -.
DR   STRING; 272631.gene:17576483; -.
DR   KEGG; mle:ML2617; -.
DR   Leproma; ML2617; -.
DR   eggNOG; COG2409; Bacteria.
DR   HOGENOM; CLU_005108_2_0_11; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1014
FT                   /note="Probable transport protein MmpL11"
FT                   /id="PRO_0000103579"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        530..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        560..580
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        598..618
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        649..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        671..691
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          783..802
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1014 AA;  109876 MW;  5BB0D797AFF58D79 CRC64;
     MMRLSSYLRR FRWLVFTGWL LALVPAIYLA MTQSGKLTGG GFEVAGSQSL LVHDQLQEQY
     PDQGAVSLAL VAAPRSDASY QDMNDAVALL RRIVSEFPGV SEVPNPTQLP PRPDRPYGVS
     LRLDDRNSVT SDVAKQLRTK VGIKGDQAGR TANGKVRLYV IGQGALSAAV AANSKHDIAE
     AERWNLPIIL IVLLAVFGSL AAAAVPLALG VCTVVVTMGL VDLVSMHTIM SVFVTSTVSM
     FGIALAVDYS LFILMRFREE LRSGRQPQEA VDAAMATSGL AVVLSGMTVI ASLTGIYLIN
     TAALKSMATG AILAVAIAML ASITLTPAAL ATFGRAAVKR SVLMHWSQRS ECTQSLFWTR
     WVGWVMHRPW ISASAASTIL IIMATPVTSM MLGNSLLRQF NSSHEIRAGV AAAAQALGPG
     ALGPVQVLIT FPDDPNTQAS SPKHRQTIGA IRNRMLQAKN VMSVAPPQFA DNNCSALLGA
     VLSVDPEDLG ARETVDWMRT ELPKVPGAAH VNVGGPTALI NDFDDRVAKT EPLMLVFVAL
     IAFVMLLISI RSVFLAFKGV LMTLLSVAAA YGSLVMVFQW GWLENLGFTH INSIDSTVPP
     LVLAMTFGLS MDYEIFLLTR IRERFLQTGH TRDAVAYGVS TSARTITSAA LIMIAVFVGF
     AFAGMPLVAE IGVACAVAIA VDVTAVRLVL VPTLMAMFAQ WNWWLPRWLS RALPAVDFDK
     PFPPVDLNEI VVLPADISAT KVPCGDLRMV LKLAAKLKNL APDAICVADP LAFTGCGRNN
     KRSDRVLPGA ATQESEEDPA MGKASDSTAA LTAAQVGPVT RTNGHWTARN LVIGLTHRNS
     ITRVMPWSDR PVHPFTLWRS RFSVAIDALE AHIAVQADAP DQPNYQRCSP VETAHVQLPT
     GDRLLIPTGA ETLRLVSYLI MCRNSIRDYA ELADMVDAIE PETAAVVLTE LDRYYSCQLP
     MRQWMATQLV RRLSDPHPVD LTEDQWSDPD NKAEWQDVRQ RCLSVAVAML EEAR
//