ID   MQO_BLOFL               Reviewed;         524 AA.
AC   Q7VRS0;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Bfl529;
OS   Blochmannia floridanus.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; ant endosymbionts; Blochmannia.
OX   NCBI_TaxID=203907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12886019; DOI=10.1073/pnas.1533499100;
RA   Gil R., Silva F.J., Zientz E., Delmotte F., Gonzalez-Candelas F.,
RA   Latorre A., Rausell C., Kamerbeek J., Gadau J., Hoelldobler B.,
RA   van Ham R.C.H.J., Gross R., Moya A.;
RT   "The genome sequence of Blochmannia floridanus: comparative analysis of
RT   reduced genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:9388-9393(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; BX248583; CAD83215.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7VRS0; -.
DR   STRING; 203907.Bfl529; -.
DR   KEGG; bfl:Bfl529; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_6; -.
DR   OrthoDB; 9763983at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002192; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   NCBIfam; TIGR01320; mal_quin_oxido; 1.
DR   PANTHER; PTHR43104; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43104:SF2; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..524
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000128709"
SQ   SEQUENCE   524 AA;  59985 MW;  CC4BA26622C5B1EB CRC64;
     MKNSIFKNKY NSTQYNLNSS VDIVLVGAGI MSVTLGSFLT ILEPSWIIHI YERLNKPAQE
     SSNSWNNAGT GHAAFCELNY TKYNKINDSI DITKALSINT AFELSLQFWA FLTKNGIINN
     PKSFINNIPH ISFVWGQKNI NFLKKRFQTL QTHNLFHGMI YSEDPHQIKS WIPLVMTGRN
     NNQKVAATYM PMGTDINFEE ITTQLLAQLK KNPNFNIYLE HDVTHIERHN NKYWKISVQD
     IQHKKTIHTY TKYVFIGAGG KSLNLLQTAN IQSVSGYAGF PVGGQFLVTY NPEIVSQHQA
     KVYGKANVSM PPMSVPHIDT RILNNKKVLL FGPFATFSSK FLKYGSWLDL FHSLNKHNLK
     PIIQAGIDNF PLIKYLFNQL IMSNHDRINA LKEYYPEVNS KDWFLIQAGQ RVQIIKKNNK
     NRGILQFGTE IVSSADGSLS ALLGASPGAS ISVSITIKLL NIMFQNKYYN DLWKTKLIEI
     VPSYINPTLN NYHSDFMKQI RKNTRNILKL IYIEKENRSL IFKK
//