ID MSRR_STAAM Reviewed; 327 AA.
AC Q931S1;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Regulatory protein MsrR;
GN Name=msrR; OrderedLocusNames=SAV1362;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC and teicoplanin, as well as the synthesis of virulence factors (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family. {ECO:0000305}.
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DR EMBL; BA000017; BAB57524.1; -; Genomic_DNA.
DR RefSeq; WP_000356978.1; NC_002758.2.
DR AlphaFoldDB; Q931S1; -.
DR SMR; Q931S1; -.
DR DNASU; 1121337; -.
DR KEGG; sav:SAV1362; -.
DR HOGENOM; CLU_016455_1_0_9; -.
DR PhylomeDB; Q931S1; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.630.190; LCP protein; 1.
DR InterPro; IPR004474; LytR_CpsA_psr.
DR NCBIfam; TIGR00350; lytR_cpsA_psr; 1.
DR PANTHER; PTHR33392; POLYISOPRENYL-TEICHOIC ACID--PEPTIDOGLYCAN TEICHOIC ACID TRANSFERASE TAGU; 1.
DR PANTHER; PTHR33392:SF8; REGULATORY PROTEIN MSRR; 1.
DR Pfam; PF03816; LytR_cpsA_psr; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Signal-anchor; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix.
FT CHAIN 1..327
FT /note="Regulatory protein MsrR"
FT /id="PRO_0000218503"
FT TOPO_DOM 1..31
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..327
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 36970 MW; 0CF23D96399F3074 CRC64;
MDKETNDNEY RRQSEHRTSA PKRKKKKKIR KLPIILLIVV ILLIALVVYI VHSYNSGVEY
AKKHAKDVKV HQFNGPVKND GKISILVLGA DKAQGGQSRT DSIMVVQYDF INKKMKMMSV
MRDIYADIPG YGKHKINSAY ALGGPKLLRK TLDKNLGINP EYYAVVDFTG FEKMIDELMP
EGVPINVEKD MSKNIGVSLK KGNHRLNGKE LLGYARFRHD PEGDFGRVRR QQQVMQTLKK
EMVNFRTVVK LPKVAGILRG YVNTNIPDSG IFQTGLSFGI RGEKDVKSLT VPIKNSYEDV
NTNTDGSALQ INKNTNKQAI KDFLDED
//
