ID MUTS_BACCQ Reviewed; 892 AA.
AC B9IV59;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BCQ_3555;
OS Bacillus cereus (strain Q1).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=361100;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Q1;
RX PubMed=19060151; DOI=10.1128/jb.01629-08;
RA Xiong Z., Jiang Y., Qi D., Lu H., Yang F., Yang J., Chen L., Sun L., Xu X.,
RA Xue Y., Zhu Y., Jin Q.;
RT "Complete genome sequence of the extremophilic Bacillus cereus strain Q1
RT with industrial applications.";
RL J. Bacteriol. 191:1120-1121(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000227; ACM13983.1; -; Genomic_DNA.
DR AlphaFoldDB; B9IV59; -.
DR SMR; B9IV59; -.
DR KEGG; bcq:BCQ_3555; -.
DR HOGENOM; CLU_002472_3_2_9; -.
DR Proteomes; UP000000441; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..892
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000192197"
FT REGION 833..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 892 AA; 101138 MW; 292D0F6DF6BB80D8 CRC64;
MTQYTPMIQQ YLKVKADYQD AFLFFRLGDF YEMFFEDAVK AAHELEITLT SRDGGSSERI
PMCGVPYHAA KNYIEQLVEK GYKVAVCEQV EDPKTAKGVV RREVVQLITP GTMMEGRTID
EKENNFLAAL THFEDGSYAL ACNDLTTGQN TVTLLTGSVE DILLEVYATG SKEIVVDSSF
SKDELNKLTE TLKMTISYED ATAIPEGLEH LVKNVSQAKL IKAVGRLFNY VIRTQKRSLD
HLQPVEIYYT NQFMKIDVHS KRNLELTETL RTKEKTGSLL WLLDKTKTAM GGRMLKQWME
RPLIQKERIE ERLEMVETFV NDYFLREDLK EKLKEVYDLE RLAGKVAFGN VNARDLLQLR
RSLLQVPAIL EAISLLDNAY AARLIQGADP CESLTELLGR SIQENPPLSI KDGDIIKDGY
NDKLDQYRYV SKNGKTWIAE LEKRERDITG IKSLKIGYNR IFGYYIEVTK ANLGALPEGR
YERKQTLANA ERFITDELKE KETLILEAEE KIVQLEYDLF TALREEVKVF IPKLQHLAKV
ISELDVLQSF ATVSEEEQFV KPVLTTKREI FIKDGRHPVV EKVLNGKLYV PNDCIMPENM
DVFLITGPNM SGKSTYMRQL ALVTVMSQIG CFVPATEAVL PVFDQIFTRI GAADDLISGQ
STFMVEMLEA KNAIANASER SLILFDEIGR GTSTYDGMAL AQAIIEHIHD QIGAKTLFST
HYHELTVLEE SLDQLKNVHV SAIEENGKVV FLHKIQDGAA DKSYGIHVAQ LAELPDSLIA
RAKEVLAQLE GQEEIIIPKR VEVKMQEQEV IPEPVVVKEA PVEIEETKVE NEEESQLSFF
GGEQSPKKQD KPVLDTKETA VLAQIKKIDL LDMTPLEAMN ELYRLQKKLK KG
//
