ID MUTS_COXBU Reviewed; 859 AA.
AC Q83CQ2;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CBU_1056;
OS Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Coxiella.
OX NCBI_TaxID=227377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSA 493 / Nine Mile phase I;
RX PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA Fraser C.M., Heidelberg J.F.;
RT "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO90571.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE016828; AAO90571.2; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_820057.2; NC_002971.3.
DR RefSeq; WP_010957974.1; NC_002971.4.
DR AlphaFoldDB; Q83CQ2; -.
DR SMR; Q83CQ2; -.
DR STRING; 227377.CBU_1056; -.
DR EnsemblBacteria; AAO90571; AAO90571; CBU_1056.
DR GeneID; 1208957; -.
DR KEGG; cbu:CBU_1056; -.
DR PATRIC; fig|227377.7.peg.1047; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000002671; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..859
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115092"
FT BINDING 622..629
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 859 AA; 97336 MW; 40FAFFFCDAD2166F CRC64;
MELQTKSPTT QNDFSQHTPM MRQYLRIKAE YPDLLVFYRM GDFYELFYDD AKKAAKLLNI
TLTARGQSAG HAIPMAGVPY HAVENYLTKL VRLGESVVIC EQIGDPATSK GPVAREVTRI
ITPGTVSDEA LLDEHRDNTL MVIHQEKDRF GIATLDITSG RFLIQEIISE NALFAEIERI
RPAELLISEE NSVHPLKADS IKRRPPWEFD HATALTLLCQ QFQTKSLDGF GITHLPLAIT
AAGCLLQYVN YTQKSALPHI HSIQAEQNEE ALFIDANTRR NLELITNLQG EEVHSLAWLL
DHTATPMGSR LLRRWINRPL RDQILLQQRQ NAVSTLLEKR NYSEIYENLR HIGDLERIVA
RIALRSARPR DLMQLRQALG VLPTLHQQLT NLPLNKQLQE IKNNLGLFDE LFRLLKKAII
ENPPIVIRDG GVIADGYDAP LDELRNMSTN SHQFLIDLEQ QERERTKINT VKVGYNRIHG
YYIEISRAQA KQAPTEYIRR QTLKNVERYI TPELKIFEDK VLSSRSRALA REKELYEQLL
DTLIEKLIPL QQCASAIANL DVLNTLAERA DTLNFNAPQF CDYPIIKIEA GRHPIVENVM
TDPFMPNDTH LDEKRRMLII TGPNMGGKST YMRQTALITL LAYIGSFVPA KNAQLGPIDR
IFTRIGAADD LASGRSTFMV EMTETAAILH NATEESLVLM DEVGRGTSTF DGLSLAYACA
SYLATKLKAF ALFATHYFEL TALASTLQAV KNVHLDAVEH EEKIIFLHAL REGPANKSYG
LQVAQLAGIP RSVIQHARQK LEELENPVIS ETQQPQQNEL FLPIENPVLT QLDKLNPDNL
TPKQALDILY QLIQLRQQK
//
