ID MUTS_LEGPL Reviewed; 846 AA.
AC Q5WVP6;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=lpl1769;
OS Legionella pneumophila (strain Lens).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=297245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lens;
RX PubMed=15467720; DOI=10.1038/ng1447;
RA Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L.,
RA Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J.,
RA Glaser P., Buchrieser C.;
RT "Evidence in the Legionella pneumophila genome for exploitation of host
RT cell functions and high genome plasticity.";
RL Nat. Genet. 36:1165-1173(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR628337; CAH16008.1; -; Genomic_DNA.
DR RefSeq; WP_011215778.1; NC_006369.1.
DR AlphaFoldDB; Q5WVP6; -.
DR SMR; Q5WVP6; -.
DR KEGG; lpf:lpl1769; -.
DR LegioList; lpl1769; -.
DR HOGENOM; CLU_002472_4_0_6; -.
DR Proteomes; UP000002517; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..846
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224379"
FT BINDING 610..617
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 846 AA; 94934 MW; A1FBB86A6F8C7A91 CRC64;
MASSHTPMMQ QYLRIKTDYP DMLLFYRMGD FYELFFDDAK RASQLLDLTL THRGQSADKP
IPMAGVPYHA VENYLARLLK KGESVAICEQ IGDPATSKGP VERQVTRIIT PGTVTDEALL
DARKDNILLA IHTQKQKIGI AWVDLGGGRF HLQELTEEHQ LNAELVRLQP AELLCKESTP
LPSFCSNFAV KFRPGWEFDA SNAHKLLCEQ FSVTDLSAFG EQNYPTALIA AGALLAYLKT
TQKQSLPHLT TLTLEQSEDY LQLDASTQRH LELFENIHGG GEHCLLSILD KTACAMGSRL
LKRWLGKPLK QHAIIQTRQQ AIKEIIFLQQ DVSLHQLIKQ CADVERIVSR IALKSARPRD
LVSLLQTLIL LPAIHDELQE NKTLLINEIK KEISPLPLLQ QLLETAIIDN PPMLIRDGGV
IAPGFDEELD ELRNLSSNAH ETLVKLEQEE KNRTGLSTLK LGYNSVQGFY IELSKAQAQN
APPHFHRKQT LKNVERYITP ELKLFEDKVL SAQSKALARE KWLYDNLLEE IQQYIPELSD
LAKSLAQLDV LVTLTERAQS LNWNCPNLVP ESGIMIQAGR HPVIEPLLQE RFIANDLELK
PNQNMLLITG PNMGGKSTYM RQTALIVLLA HIGSFVPADE VRLGPLDRIF TRIGASDDLS
SGRSTFMVEM TETAQILRQA TSQSLVLIDE IGRGTSTYDG MALAYASCAF LASTIKAYTL
FSTHYLELTE LPKDFSCIRN VHLQASIKTG QIVFLYRVEE GCANRSYGLE VAELAGIPKE
VLKLAHEHLN QIQDTQSILV QTQIIKPPTS PILTELKKID PDRLTAKEAL DLIYKLKQLE
CVESIN
//
