ID MUTS_RICAE Reviewed; 890 AA.
AC C3PN02;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RAF_ORF0375;
OS Rickettsia africae (strain ESF-5).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=347255;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ESF-5;
RX PubMed=19379498; DOI=10.1186/1471-2164-10-166;
RA Fournier P.-E., El Karkouri K., Leroy Q., Robert C., Giumelli B.,
RA Renesto P., Socolovschi C., Parola P., Audic S., Raoult D.;
RT "Analysis of the Rickettsia africae genome reveals that virulence
RT acquisition in Rickettsia species may be explained by genome reduction.";
RL BMC Genomics 10:166-166(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP001612; ACP53312.1; -; Genomic_DNA.
DR AlphaFoldDB; C3PN02; -.
DR SMR; C3PN02; -.
DR KEGG; raf:RAF_ORF0375; -.
DR HOGENOM; CLU_002472_3_1_5; -.
DR Proteomes; UP000002305; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..890
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000202743"
FT BINDING 645..652
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 890 AA; 100410 MW; DD81D640FE2577D1 CRC64;
MLLNMNLQEL KQKYNYDVAT KMMQQYLDIK FAHLDCLLLF RMGDFYEMFY EDAILASNVL
GIALTKRGKN GEEEIAMCGV PYHALENYLT KLIEANYKVA ICDQLETPEE AKNRGGYKAV
VTRDVTRIIT PGTIIEENLI ASAEPNYLAS LVIPKNKETA SLCYVDLSTS EIVVVNVPET
EILNELARLK PREILLSENL RSSNLADSIF KQLNLRITYQ VDSFFAINKC EKIILDFYKM
KDIKGIGEIS SSQICAIGSV LEYLSLTQKQ NIPHLPIPRI IKFHSYMTID FSTRRNLEIV
TNSQGGSQGS LLSTLNHTVT KQGGRLLYNF LSSPLTNIAK INHRLNITEF FYSNLEIVKK
IRELLKKTSD IERCLTRITM NRSSGRDLLS IKYTLETATI IKGVFFDAYG FNLPDFIEKI
IKPLSGDAEL YNLIDETIRE DAPNNLNDGG IIKHEYHPKV AQLHDLINNG KLYIEKLKDQ
YRKETGIDSL KISHNNVIGL FIDITAKNVN KILDPKFIHR QTTVNHVRYT TAELQKLESE
LVNAKTLVIS LEKELYADIC SQVIEKASYL RILASSLSGL DVFCNFAYIA DEYDYVKPEF
TDDLSFDIVK GRHPVVEKAL QRESKSFVYN DCHLSELERI WLITGPNMAG KSTFLRQNAI
IAIIAQIGSF VPAKSAKIGV VDKIFSRIGA ADDLIKGQST FMAEMLETSA ILAQSTKNSL
IILDEVGRGT STYDGVSIAW SVLEYIHDKL KCRCLFATHY HELTVMSNFL PALQNYTIAI
EESGKDILFL HNIISGAADR SYGLHVASLA GLPASVINRA EQILLKFEKT STGKGKNILS
TESNNLSLFY LEPNKTTISS KLDKKFRTID PDKLSPKEAL ELIYELKKLV
//