ID MUTS_SORC5 Reviewed; 918 AA.
AC A9GIM9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=sce3129;
OS Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So
OS ce56)).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=448385;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=So ce56;
RX PubMed=17965706; DOI=10.1038/nbt1354;
RA Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M.O.,
RA Bartels D., Bekel T., Beyer S., Bode E., Bode H.B., Bolten C.J.,
RA Choudhuri J.V., Doss S., Elnakady Y.A., Frank B., Gaigalat L., Goesmann A.,
RA Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C.,
RA Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T.,
RA Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S.,
RA Munoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F.,
RA Rueckert C., Sasse F., Scharfe M., Schuster S.C., Suen G.,
RA Treuner-Lange A., Velicer G.J., Vorholter F.-J., Weissman K.J., Welch R.D.,
RA Wenzel S.C., Whitworth D.E., Wilhelm S., Wittmann C., Bloecker H.,
RA Puehler A., Mueller R.;
RT "Complete genome sequence of the myxobacterium Sorangium cellulosum.";
RL Nat. Biotechnol. 25:1281-1289(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AM746676; CAN93288.1; -; Genomic_DNA.
DR RefSeq; WP_012235760.1; NC_010162.1.
DR AlphaFoldDB; A9GIM9; -.
DR SMR; A9GIM9; -.
DR STRING; 448385.sce3129; -.
DR KEGG; scl:sce3129; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_7; -.
DR OrthoDB; 9802448at2; -.
DR BioCyc; SCEL448385:SCE_RS16035-MONOMER; -.
DR Proteomes; UP000002139; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..918
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335227"
FT BINDING 662..669
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 918 AA; 97551 MW; B36868B4238D15B0 CRC64;
MQPSEQPAAR KKLTPVMRQY EDAKALHPDA ILFFRMGDFY EMFNDDAVLV SRALNLTLTS
RNKGEPDESP MAGVPHHAAH GYIARLLALG HKVAICEQCG DPSKIKGLVP RQVVRVVTPG
LVTETEQLDA RANHYLAAVD GGGAPRGDAL GAGGPYGLSL LDLSTGELSA TSVPDAATLL
AELARADPRE ALIARDLPDV RAAAASLACR AALRDDEELD SAHVASILDD AAIEPISAAA
LAEHPLPAVR AAARALRFAR RCSPGARIPV RRIAPHDTSG TLRIDETAQA HLELVRAADG
GRRGTLLDVI DCTVTPGGAR LLRRRLLSPL ADLAGIRRRL DEVELFVSHP RARGELRQAL
GGVGDLERLS VRALLGEATP RDLGLLRDGL TAAPAAIAAV RSIPDLGKAA ARSDDGAAAR
GKDGAAAGSS SGSEPLLAEA AALDVVADVC AELTAALIER PPPNTREGGI FREGYDKELD
DARGVEKNAT ELILALEAKL RTQTGAPSLR VKYTRVFGWY IEVTRAHIAK VPETFRRKQT
VATGERYTSD ELDELADKIE HAGARALERE TALFDRLRAL VAKSEGRLRA LARKLAAWDV
AAALADVAHR NDYVRPHVTA GEALAIRDGR HPVVERYAAA GHFVPNDTRL DLSGERLWLI
TGPNMAGKST LMRQVALIVV LAQMGSYVPA REAEIGLVDR ILSRVGASDN VARGESTFMV
EMRETAEILR DATRRSLVIL DEIGRGTSTY DGLAIAWAVA EHLFDAIGCR ALFATHYHEL
TELSARAPGI ANYSVAAREH GDDVIFLHKL EAGPASRSYG VAVARLAGVP EGVLARARAI
LATLESGAAL PGGKHASLRG RTRGGAAQLD LFAPAQAAVP PEQSAVIETL RAVDVDRLAP
LDALRLVAKL KGLLGGGG
//
