ID MUTS_SYNY3 Reviewed; 878 AA.
AC P73769;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 27-MAR-2024, entry version 140.
DE RecName: Full=DNA mismatch repair protein MutS;
GN Name=mutS; OrderedLocusNames=sll1165;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae;
OC Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA17821.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BA000022; BAA17821.1; ALT_INIT; Genomic_DNA.
DR PIR; S74860; S74860.
DR AlphaFoldDB; P73769; -.
DR SMR; P73769; -.
DR IntAct; P73769; 3.
DR STRING; 1148.gene:10498689; -.
DR PaxDb; 1148-1652903; -.
DR EnsemblBacteria; BAA17821; BAA17821; BAA17821.
DR KEGG; syn:sll1165; -.
DR eggNOG; COG0249; Bacteria.
DR InParanoid; P73769; -.
DR PhylomeDB; P73769; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..878
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115155"
FT BINDING 656..663
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 878 AA; 97586 MW; 4F2B8C58CE74D558 CRC64;
MTDTPILGTV KEPQRDYRTL DRQKLTPMFQ HYTEVKEQYQ GALLLYRVGD FFECFFQDAV
IIARELELIL TSKEGGKEIG RVAMTGVPHH ALDRYARQLV EKGYAVAICD QVEDAAEAQA
EKRMVERQVT KLLTPGTLTD DSMLPAKRNN FLAAIAMVED KWGLAHADIS TGEFFTCQSS
NLDDLAVELL RLQPSEVLIP TSAPDIRNIL RPGEPSEHIP KQLPTSFCYS LRSQAPFSLV
EAKQRLLTTF RVKSLEGMGC EGLPLAIRAA GGLLEYIEDT QKAHVVPIQP LKTYGLTDFL
VLDHQTRRNL EINQTVRDGS FHGSLLWALD RTSTTMGSRA LRRWLLQPLL DLKGIQARQD
TIQELYHHPA LRQDLRQLLR QIYDLERLTG RIGANTASAR DVYGLASSLV RLTDLAELAQ
EGHSPYLKAL QTVPPELEEL GKYVLAHIVE NPPLHIREGN LIRSGVNPTL DEMRQSLEDD
NQWLANLEVT EREKTGIANL KVGYNKAFGY YLSLPRSKSE QAPDNYIRKQ TLVNEERYIT
PELKERETRI LTAQADLNQL EYEIFTEVRA TVAEKAQPIR DVAKAVAAID VLAGLAEVAV
YQGYCRPIMQ MEPGLIDIEA GRHPVVEQSL GAGFFVANDT QLGHDHWHPD LVILTGPNAS
GKSCYLRQVG LIQLMAQTGS FIPAKTATLS ICDRIFTRVG AVDDLATGQS TFMVEMNETA
NILNHATAKS LVLLDEIGRG TATFDGLAIA WSVAEYLAGE IQARTIFATH YHELNELASL
LENVANFQVT VKELPEEIIF LHQVTPGGAD KSYGIEAGRL AGLPSSVITR ARQVMAQIEK
HSKIAVGLRK GNRGKVMASQ AAAEAAEDQA KQLDIFGF
//
