ID MUTS_YERP3 Reviewed; 851 AA.
AC A7FLX1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=YpsIP31758_3292;
OS Yersinia pseudotuberculosis serotype O:1b (strain IP 31758).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=349747;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP 31758;
RX PubMed=17784789; DOI=10.1371/journal.pgen.0030142;
RA Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G.,
RA Fayolle C., Lindler L.E., Carniel E., Ravel J.;
RT "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the
RT causative agent of Far East scarlet-like fever.";
RL PLoS Genet. 3:1508-1523(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000720; ABS47648.1; -; Genomic_DNA.
DR RefSeq; WP_011191781.1; NC_009708.1.
DR AlphaFoldDB; A7FLX1; -.
DR SMR; A7FLX1; -.
DR GeneID; 66842801; -.
DR KEGG; ypi:YpsIP31758_3292; -.
DR HOGENOM; CLU_002472_4_0_6; -.
DR Proteomes; UP000002412; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..851
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000057639"
FT BINDING 614..621
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 851 AA; 94786 MW; DF141372BE6F3D13 CRC64;
MKNNDKLDSH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YSDAKRASQL LDISLTKRGA
SAGEPIPMAG VPYHSIENYL AKLVQLGESA AICEQIGDPA TSKGPVERKV VRIVTPGTIS
DEALLQERQD NLLAAIWQDA KGFGYATLDI SSGRFRVAEP ADLETMAAEL QRTNPAELLY
PENFEPMSLI EHRHGLRRRP LWEFELDTAK QQLNLQFGTR DLIGFGVEQA HLALRAAGCL
LQYVKDTQRT SLPHIRGLTM ERQQDGIIMD AATRRNLELT QNLSGGSENT LAAILDCSVT
PMGSRMLKRW LHMPIRDIRV LTDRQQAIGG LQDIAAELQT PLRQVGDLER ILARLALRTA
RPRDLARMRH AFQQLPEIHR LLQPIDVPHV QNLLSQVGQF DELQDLLERA IVETPPVLVR
DGGVIASGYN AELDEWRALA DGATDYLDRL EIREREKLGL DTLKVGFNGV HGYYIQVSRG
QSHLVPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LAIEKGLYEE IFDLLLPHLP
ELQLSANALA ELDVLANLAE RAETLNYSCP TLSDKPGIKI MGGRHPVVEQ VLKEPFISNP
LTLSPQRRML IITGPNMGGK STYMRQTALI VLLAHLGSYV PADQATIGPI DRIFTRVGAA
DDLASGRSTF MVEMTETANI LHNATEQSLV LMDEIGRGTS TYDGLSLAWA CAENLASRIK
AMTLFATHYF ELTTLPEKME GVANVHLDAL EHGETIAFMH SVQEGAASKS YGLAVAALAG
VPRDVIKRAR QKLKELESLS NNAAASTIDG SQMTLLNEEI PPAVEALEAL DPDSLSPRQA
LEWIYRLKNM V
//
