ID MYCL_MOUSE Reviewed; 368 AA.
AC P10166; Q5FWI7;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 24-JAN-2024, entry version 173.
DE RecName: Full=Protein L-Myc;
GN Name=Mycl; Synonyms=Lmyc1, Mycl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RX PubMed=2828024; DOI=10.1002/j.1460-2075.1987.tb02657.x;
RA Legouy E., DePinho R.A., Zimmerman K., Collum R., Yancopoulos G.D.,
RA Mitsock L., Kriz R., Alt F.W.;
RT "Structure and expression of the murine L-myc gene.";
RL EMBO J. 6:3359-3366(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Binds DNA as a heterodimer with MAX.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; X13945; CAA32128.1; -; Genomic_DNA.
DR EMBL; BC053059; AAH53059.1; -; mRNA.
DR EMBL; BC089346; AAH89346.1; -; mRNA.
DR CCDS; CCDS18606.1; -.
DR PIR; S03017; TVMSML.
DR RefSeq; NP_001290050.1; NM_001303121.1.
DR RefSeq; NP_032532.1; NM_008506.3.
DR RefSeq; XP_006502884.1; XM_006502821.3.
DR AlphaFoldDB; P10166; -.
DR SMR; P10166; -.
DR BioGRID; 201184; 1.
DR IntAct; P10166; 1.
DR STRING; 10090.ENSMUSP00000030407; -.
DR iPTMnet; P10166; -.
DR PhosphoSitePlus; P10166; -.
DR PaxDb; 10090-ENSMUSP00000030407; -.
DR PeptideAtlas; P10166; -.
DR Antibodypedia; 17920; 184 antibodies from 27 providers.
DR DNASU; 16918; -.
DR Ensembl; ENSMUST00000030407.8; ENSMUSP00000030407.8; ENSMUSG00000028654.14.
DR Ensembl; ENSMUST00000106252.9; ENSMUSP00000101859.3; ENSMUSG00000028654.14.
DR GeneID; 16918; -.
DR KEGG; mmu:16918; -.
DR UCSC; uc008uop.2; mouse.
DR AGR; MGI:96799; -.
DR CTD; 4610; -.
DR MGI; MGI:96799; Mycl.
DR VEuPathDB; HostDB:ENSMUSG00000028654; -.
DR eggNOG; ENOG502QWSU; Eukaryota.
DR GeneTree; ENSGT00940000158613; -.
DR HOGENOM; CLU_052560_0_0_1; -.
DR InParanoid; P10166; -.
DR OMA; RWEMEYD; -.
DR OrthoDB; 3039999at2759; -.
DR PhylomeDB; P10166; -.
DR TreeFam; TF106001; -.
DR BioGRID-ORCS; 16918; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Mycl; mouse.
DR PRO; PR:P10166; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P10166; Protein.
DR Bgee; ENSMUSG00000028654; Expressed in urinary bladder urothelium and 238 other cell types or tissues.
DR ExpressionAtlas; P10166; baseline and differential.
DR Genevisible; P10166; MM.
DR GO; GO:0005694; C:chromosome; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045607; P:regulation of inner ear auditory receptor cell differentiation; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11457; bHLHzip_L-Myc; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1.
DR PANTHER; PTHR45851:SF5; PROTEIN L-MYC-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF01056; Myc_N; 2.
DR PIRSF; PIRSF001705; Myc_protein; 1.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..368
FT /note="Protein L-Myc"
FT /id="PRO_0000127334"
FT DOMAIN 285..337
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 39..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..365
FT /note="Leucine-zipper"
FT COMPBIAS 132..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..260
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 368 AA; 40848 MW; 9174F6FD7C03321E CRC64;
MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG AVDPASGINP
GEPWPGGGAG DEAESRGHSK AWGRNYASII RRDCMWSGFS ARERLERVVS DRLAPGAPRG
NPPKAPATPD GTPSLEASNP APATQCQLGE PKTQACSGSE SPSDSEGEEI DVVTVEKRRS
LDIRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP ESCSQEGDPE PGPQEEAPEI
EAPKEKEEEE EEEEEEEIVS PPPVGSEAPQ SCHPKPVSSD TEDVTKRKNH NFLERKRRND
LRSRFLALRD QVPTLASCSK APKVVILSKA LEYLQALVGA EKKMATEKRQ LRCRQQQLQK
RIAYLSGY
//
