ID N1J5F9_BLUG1 Unreviewed; 450 AA.
AC N1J5F9;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 28-JUN-2023, entry version 45.
DE SubName: Full=Aspartic protease/pepsin like protease/pepsin-like protease {ECO:0000313|EMBL:CCU74651.1};
GN ORFNames=BGHDH14_bgh00494 {ECO:0000313|EMBL:CCU74651.1};
OS Blumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew)
OS (Oidium monilioides f. sp. hordei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Blumeria; Blumeria hordei.
OX NCBI_TaxID=546991 {ECO:0000313|EMBL:CCU74651.1, ECO:0000313|Proteomes:UP000015441};
RN [1] {ECO:0000313|EMBL:CCU74651.1, ECO:0000313|Proteomes:UP000015441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH14 {ECO:0000313|EMBL:CCU74651.1};
RX PubMed=21148392; DOI=10.1126/science.1194573;
RA Spanu P.D., Abbott J.C., Amselem J., Burgis T.A., Soanes D.M., Stueber K.,
RA Ver Loren van Themaat E., Brown J.K.M., Butcher S.A., Gurr S.J.,
RA Lebrun M.-H., Ridout C.J., Schulze-Lefert P., Talbot N.J., Ahmadinejad N.,
RA Ametz C., Barton G.R., Benjdia M., Bidzinski P., Bindschedler L.V.,
RA Both M., Brewer M.T., Cadle-Davidson L., Cadle-Davidson M.M., Collemare J.,
RA Cramer R., Frenkel O., Godfrey D., Harriman J., Hoede C., King B.C.,
RA Klages S., Kleemann J., Knoll D., Koti P.S., Kreplak J., Lopez-Ruiz F.J.,
RA Lu X., Maekawa T., Mahanil S., Micali C., Milgroom M.G., Montana G.,
RA Noir S., O'Connell R.J., Oberhaensli S., Parlange F., Pedersen C.,
RA Quesneville H., Reinhardt R., Rott M., Sacristan S., Schmidt S.M.,
RA Schoen M., Skamnioti P., Sommer H., Stephens A., Takahara H.,
RA Thordal-Christensen H., Vigouroux M., Wessling R., Wicker T., Panstruga R.;
RT "Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in
RT extreme parasitism.";
RL Science 330:1543-1546(2010).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCU74651.1}.
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DR EMBL; CAUH01000478; CCU74651.1; -; Genomic_DNA.
DR AlphaFoldDB; N1J5F9; -.
DR STRING; 546991.N1J5F9; -.
DR MEROPS; A01.079; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_013253_0_1_1; -.
DR InParanoid; N1J5F9; -.
DR OrthoDB; 2900143at2759; -.
DR Proteomes; UP000015441; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06097; Aspergillopepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR034163; Aspergillopepsin-like_cat_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966:SF23; ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED; 1.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU000454}; Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:CCU74651.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015441};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..450
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004107189"
FT DOMAIN 138..447
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 82..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 154
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 339
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
SQ SEQUENCE 450 AA; 46675 MW; 887EED8D89088447 CRC64;
MLLQSQIRAL VLLAIASLSI AAPSRSHVEK RSFKVARVPN PTYMGRTPGA GTRALIKAHR
KFQFDLPQGL LDTMMASNAG AGAGVANTPQ KAATTATEKE PAAKASAGDD NSSGGADAPW
TNGTGKVTAT PVMGDVEYLS PISIGGQTIN MDFDSGSSDL WVFSSQLPAA SIGQHTVYDS
SKSSTFAPIE GATFKIAYGD GSGASGNVGT DTVNIGGATV TKQTVELATM VSQSFTADTG
SNGLVGLAFS KLNTVKPTQQ KTFFDNMIPN LSQPVFTADL RSNAVGAYEF GNIDSSKYNG
SLAWAPIDSS SGFWQFSSTK FQVADQAPID APSGKAIADT GTTLMLTSAA IVNAYYSQVT
GAVNDAQVGG VTFPCNSDLP DLKVDVGGNY MAVIRGSDIN FAPVDNARTT CFGGVQAIQS
PLQIYGDIMF KSQFVVFNGG NSSIGMAPHQ
//
