ID N1JDA0_BLUG1 Unreviewed; 1014 AA.
AC N1JDA0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=BGHDH14_bgh00746 {ECO:0000313|EMBL:CCU75897.1};
OS Blumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew)
OS (Oidium monilioides f. sp. hordei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Blumeria; Blumeria hordei.
OX NCBI_TaxID=546991 {ECO:0000313|EMBL:CCU75897.1, ECO:0000313|Proteomes:UP000015441};
RN [1] {ECO:0000313|EMBL:CCU75897.1, ECO:0000313|Proteomes:UP000015441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH14 {ECO:0000313|EMBL:CCU75897.1};
RX PubMed=21148392; DOI=10.1126/science.1194573;
RA Spanu P.D., Abbott J.C., Amselem J., Burgis T.A., Soanes D.M., Stueber K.,
RA Ver Loren van Themaat E., Brown J.K.M., Butcher S.A., Gurr S.J.,
RA Lebrun M.-H., Ridout C.J., Schulze-Lefert P., Talbot N.J., Ahmadinejad N.,
RA Ametz C., Barton G.R., Benjdia M., Bidzinski P., Bindschedler L.V.,
RA Both M., Brewer M.T., Cadle-Davidson L., Cadle-Davidson M.M., Collemare J.,
RA Cramer R., Frenkel O., Godfrey D., Harriman J., Hoede C., King B.C.,
RA Klages S., Kleemann J., Knoll D., Koti P.S., Kreplak J., Lopez-Ruiz F.J.,
RA Lu X., Maekawa T., Mahanil S., Micali C., Milgroom M.G., Montana G.,
RA Noir S., O'Connell R.J., Oberhaensli S., Parlange F., Pedersen C.,
RA Quesneville H., Reinhardt R., Rott M., Sacristan S., Schmidt S.M.,
RA Schoen M., Skamnioti P., Sommer H., Stephens A., Takahara H.,
RA Thordal-Christensen H., Vigouroux M., Wessling R., Wicker T., Panstruga R.;
RT "Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in
RT extreme parasitism.";
RL Science 330:1543-1546(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCU75897.1}.
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DR EMBL; CAUH01001849; CCU75897.1; -; Genomic_DNA.
DR AlphaFoldDB; N1JDA0; -.
DR STRING; 546991.N1JDA0; -.
DR eggNOG; KOG0478; Eukaryota.
DR HOGENOM; CLU_000995_7_0_1; -.
DR InParanoid; N1JDA0; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000015441; Unassembled WGS sequence.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IEA:UniProt.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR GO; GO:0043596; C:nuclear replication fork; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:UniProt.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008047; MCM_4.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF66; DNA REPLICATION LICENSING FACTOR MCM4; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF21128; MCM4_WHD; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01660; MCMPROTEIN4.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Cell cycle {ECO:0000313|EMBL:CCU75897.1};
KW Cell division {ECO:0000313|EMBL:CCU75897.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015441}.
FT DOMAIN 615..809
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 855..882
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 91..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1014 AA; 112776 MW; 802577DA5E978034 CRC64;
MSSPPNGQPT PFQGTHGHLG NTAARRTLQR NSSRITPSSP VDAAAAQLQT EAASSQRYVD
RDTNAFRSSS PVPYPSSPTP AHGRNIERDI SSPLRQMTTS QIQYDDNSTP RASSSRFARD
SSPIRYAPSS SPGLNSYRRS VPPDIRSDSS GLFIRSSRGE NAGPMSSLNI RRRGDINSDS
INTPRARRRI FMDESGNVTR DIPTEGSEAP TFSNLDPTTS DAAAMGGESQ LCIWGTNVSI
NDTLSTFKSF LRGFTKKYRM WADGMSEEET SQESDAETKE YIETMKNMLT LGVTSLNLDF
RNLKAYPKTQ KLWQQAQDYP QDVVTLMDQG IKDVMYELAE EETLRKRQLQ NRAIISQRNL
KASSEPLMLS SERDEFDTQE RSQEVSEDLD LCQEVQKRSY RVRPFGLEKT INMRDLNPSD
VDKIIAIKGL VIRTTPIIPD MKDAFFRCQV CNHTVKVDID RGRIAEPTKC PRPICDSPNS
MQIVHNRSEF MDKQVIKFQE TPDSVPAGQT PHSITMCAYD ELVDFCKAGD RVEITGIFKA
SPVRVNPRQR TLKNVYKTYI DVLHIQKVDK KRMGIDVSTV EQDLSEQTAT NIEEARRVSD
EEKEKILQTA MRPDIYELLS RSLAPSIFEM DDVKKGILLQ LFGGTNKTFE KGGSPKYRGD
INILLCGDPS TSKSQLLQYV HKIAPRGLYT SGKGSSAVGL TAYVTRDPET RQLVLESGAL
VLSDGGVCCI DEFDKMSDAT RSVLHEVMEQ QTVSIAKAGI ITTLNARTSI LASANPIGSK
YNPNLPIELM KQTTGRLARH LLSMYLDDKP QSASGGMEIL PVEFLTSYIS YARHTCQPRI
SAEAAEELVT AYVEMRKLGE DIRAAERRIT ATTRQLESMI RLAEAHAKMR LSDTVGRDDV
SEAVRLIKSA LKQAATDART GLIDMSLLTE GTSASERRRK ADLKRATLAL LDEMTGQGQS
ARYIEVIKRL GEQSSMPIES SEFAEVVRLL EQEGLAMVVG EGVRKAIRRL TGAA
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