ID N1JJE0_BLUG1 Unreviewed; 849 AA.
AC N1JJE0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 08-NOV-2023, entry version 39.
DE SubName: Full=DNA mismatch repair protein/mutL {ECO:0000313|EMBL:CCU79006.1};
GN ORFNames=BGHDH14_bgh00940 {ECO:0000313|EMBL:CCU79006.1};
OS Blumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew)
OS (Oidium monilioides f. sp. hordei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Blumeria; Blumeria hordei.
OX NCBI_TaxID=546991 {ECO:0000313|EMBL:CCU79006.1, ECO:0000313|Proteomes:UP000015441};
RN [1] {ECO:0000313|EMBL:CCU79006.1, ECO:0000313|Proteomes:UP000015441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH14 {ECO:0000313|EMBL:CCU79006.1};
RX PubMed=21148392; DOI=10.1126/science.1194573;
RA Spanu P.D., Abbott J.C., Amselem J., Burgis T.A., Soanes D.M., Stueber K.,
RA Ver Loren van Themaat E., Brown J.K.M., Butcher S.A., Gurr S.J.,
RA Lebrun M.-H., Ridout C.J., Schulze-Lefert P., Talbot N.J., Ahmadinejad N.,
RA Ametz C., Barton G.R., Benjdia M., Bidzinski P., Bindschedler L.V.,
RA Both M., Brewer M.T., Cadle-Davidson L., Cadle-Davidson M.M., Collemare J.,
RA Cramer R., Frenkel O., Godfrey D., Harriman J., Hoede C., King B.C.,
RA Klages S., Kleemann J., Knoll D., Koti P.S., Kreplak J., Lopez-Ruiz F.J.,
RA Lu X., Maekawa T., Mahanil S., Micali C., Milgroom M.G., Montana G.,
RA Noir S., O'Connell R.J., Oberhaensli S., Parlange F., Pedersen C.,
RA Quesneville H., Reinhardt R., Rott M., Sacristan S., Schmidt S.M.,
RA Schoen M., Skamnioti P., Sommer H., Stephens A., Takahara H.,
RA Thordal-Christensen H., Vigouroux M., Wessling R., Wicker T., Panstruga R.;
RT "Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in
RT extreme parasitism.";
RL Science 330:1543-1546(2010).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCU79006.1}.
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DR EMBL; CAUH01004177; CCU79006.1; -; Genomic_DNA.
DR AlphaFoldDB; N1JJE0; -.
DR STRING; 546991.N1JJE0; -.
DR eggNOG; KOG1978; Eukaryota.
DR HOGENOM; CLU_011171_4_0_1; -.
DR InParanoid; N1JJE0; -.
DR OrthoDB; 1369806at2759; -.
DR Proteomes; UP000015441; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF41; MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000015441}.
FT DOMAIN 216..365
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 365..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 94171 MW; 2BE5D2CBC4ED2E0F CRC64;
MSIAPLPEST VRLLGSTQVL TTPTSLVKEL IDNAIDANAT SIDIIISPNT LDKIELRDNG
HGIQREDFDS LGKRGHTSKL RSFEDLKSIG GTSLGFRGEA LFSAIQLGKV TITSKCEGEQ
IATMAKFKVM GGIESKVTTS HPIGTTVSIA DFLSSMPVRK QTSIKDAVKT IANIKELLRA
YSLARVHIRF CLKILKGGKG NWSFSPRPND GIKEAVSQII GREVASQCMK KSLLFLDTED
LSLEESNVVD NVPLDENRFF LDMFLPKQDA DFSKISYGQY LSVDGRPVSH EKGTMKKIVA
IFKRHIRNCL PETSLKSSQL FLRLDIKCPR ESYDPNVEPA KNDVIFTHES VLLGNIEKAF
QNIYDGSKSS PNLPQNTDPS NRDRSKLLLS RNVSKVPLDS YADPVESSAL QDTPTVTSRP
SKAGEIPDIA LSSPKRDVLR KQVERKISRA SSIETPSPRA PSRTLISAEI LEQLNQSPSE
NHLNPWLIAK MISPIQTKDR KLRSGRKSPT LSRCNSPSFT SSAELIQQQG PKDLPIPLSL
ARHSKSNDSN EDLMPTEECT TIHRHGFVSA KDVISQPLQN SDPTTYTNQK VRANKLPRTP
PKLDTTPTNK KMRQATLNSA VLSSRGSPGS GSDIMVNNNN DLRLSFAIDC ENRNEKATTR
PGENIGIVQQ VEKPGHDYDL RKQMARTHPK IAEADEPSLS QDTDAHITAH PTPETSLPES
DPRGYFIRQL GHFGPRIDST KGPKISRPKS SRLPLERIPI GQELHQCMVK VATSPRNLQE
IYNQFEAVDE YIQKGSRACV TATENDDLSR ISTKLKHELT RRAYSMLETF PHRPLEVASR
ALCDDSRES
//
