ID N1JKM3_BLUG1 Unreviewed; 989 AA.
AC N1JKM3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN ORFNames=BGHDH14_bgh00568 {ECO:0000313|EMBL:CCU80557.1};
OS Blumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew)
OS (Oidium monilioides f. sp. hordei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Blumeria; Blumeria hordei.
OX NCBI_TaxID=546991 {ECO:0000313|EMBL:CCU80557.1, ECO:0000313|Proteomes:UP000015441};
RN [1] {ECO:0000313|EMBL:CCU80557.1, ECO:0000313|Proteomes:UP000015441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH14 {ECO:0000313|EMBL:CCU80557.1};
RX PubMed=21148392; DOI=10.1126/science.1194573;
RA Spanu P.D., Abbott J.C., Amselem J., Burgis T.A., Soanes D.M., Stueber K.,
RA Ver Loren van Themaat E., Brown J.K.M., Butcher S.A., Gurr S.J.,
RA Lebrun M.-H., Ridout C.J., Schulze-Lefert P., Talbot N.J., Ahmadinejad N.,
RA Ametz C., Barton G.R., Benjdia M., Bidzinski P., Bindschedler L.V.,
RA Both M., Brewer M.T., Cadle-Davidson L., Cadle-Davidson M.M., Collemare J.,
RA Cramer R., Frenkel O., Godfrey D., Harriman J., Hoede C., King B.C.,
RA Klages S., Kleemann J., Knoll D., Koti P.S., Kreplak J., Lopez-Ruiz F.J.,
RA Lu X., Maekawa T., Mahanil S., Micali C., Milgroom M.G., Montana G.,
RA Noir S., O'Connell R.J., Oberhaensli S., Parlange F., Pedersen C.,
RA Quesneville H., Reinhardt R., Rott M., Sacristan S., Schmidt S.M.,
RA Schoen M., Skamnioti P., Sommer H., Stephens A., Takahara H.,
RA Thordal-Christensen H., Vigouroux M., Wessling R., Wicker T., Panstruga R.;
RT "Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in
RT extreme parasitism.";
RL Science 330:1543-1546(2010).
CC -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC {ECO:0000256|ARBA:ARBA00002558}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCU80557.1}.
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DR EMBL; CAUH01004741; CCU80557.1; -; Genomic_DNA.
DR AlphaFoldDB; N1JKM3; -.
DR STRING; 546991.N1JKM3; -.
DR eggNOG; KOG1421; Eukaryota.
DR HOGENOM; CLU_003212_0_0_1; -.
DR InParanoid; N1JKM3; -.
DR OrthoDB; 1779375at2759; -.
DR Proteomes; UP000015441; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR025926; PDZ-like_dom.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR Pfam; PF12812; PDZ_1; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW Protease {ECO:0000313|EMBL:CCU80557.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015441};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 323..371
FT /note="PDZ"
FT /evidence="ECO:0000259|Pfam:PF17820"
FT DOMAIN 388..463
FT /note="PDZ-like"
FT /evidence="ECO:0000259|Pfam:PF12812"
FT DOMAIN 840..917
FT /note="PDZ-like"
FT /evidence="ECO:0000259|Pfam:PF12812"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 989 AA; 110177 MW; B8F072578660E59F CRC64;
MNGHSPRTKR KQHPGTVAER PLKQHKITLE MDSNSPTPEE SLYEDEDMAT EIEDTRVASG
MADTAEWQAC IENVVRNVVS IRFCQTCSFD TDSALTSEAT GFVVDAERGY IMTNRHVVGA
GPFWGYCIFD NHEEVDAYPV YRDPVHDFGI LRFNPKAIKY MPVTALTLRP DLAKVGSEIR
VVGNDAGEKL SILSGVISRL DRNAPEYGEG YCDFNTNYIQ AAAAASGGSS GSPVVNIDGF
AVALQAGGRS DGAATDYFLP LDRPLRALKC IQEGKKITRG TIQCQWMIKP FDECRRLGLT
PEWEGAIRKN FPKETGMLVA EIVLPEGPSD NQVEEGDVLI KVNGELLTQF IRLDDILDSN
VGHQVKLLLQ RGGEDLEVEV TVGDLHTITP DRFVSVSGGS FHNLSYQQAR LYAVACKGVF
VCEATGSFRF EHMDNGWLIQ TVDHKKTPDL DAFIEVMKNI PDRARVVVTY KHLRDLHTLN
TSILTIDRHW SSKMRLAVRN DSTGLWDFSD IADPLPALPP VPRSASFIQL SNTQHPAAAD
IVRSFVRVLC HMPMKLDGFP RNRKWAMGVV IDADKGLVVI SRAIVPYDLC DITITIADSI
IVEGKVIFMH PLQNYAVIKE PPLILLALTK NMRVVIAQTN VTDITAVAIP ANTVAPRYRA
VNVDAITVDT SLSSQCGSGV LVSEDGTVQA LWLTYLGERS PSTQKDTDYH LGLATPTLLP
VIRKIQQDEI PRLRMLSVEF NAIQMSQARI MGVSEEWIKK VAEDNHSRHQ LFMVRKRTFE
RGDETAALVE GDVILTLNGK IITRVSELDV MYDNDYLDAL ILRDCVEISL KLPTVSANDL
ETDRAVSFCG AVLHRPHHAV RQQISKLHSE VYVSARTRGS PAYQYGLTPT NFVTHVNGRP
TKNIEDFLNV VVPIPDNTYF RVRAMTFDNV PWVITMKKNE HYFPTTEWIK DHLEPCGWRR
VTYEEGQAIT GEGHDGLSII TGECFESEG
//
