ID   N1NWR8_YEASC            Unreviewed;       342 AA.
AC   N1NWR8;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Gre2p {ECO:0000313|EMBL:EIW07406.1};
GN   ORFNames=CENPK1137D_1993 {ECO:0000313|EMBL:EIW07406.1};
OS   Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=889517 {ECO:0000313|EMBL:EIW07406.1};
RN   [1] {ECO:0000313|EMBL:EIW07406.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CEN.PK113-7D {ECO:0000313|EMBL:EIW07406.1};
RA   Nijkamp J.F., van den Broek M.A., Datema E., de Kok S., Bosman L.,
RA   Luttink M.A., Daran-Lapujade P., Vongsangnak W., Nielsen J., Heijne W.H.M.,
RA   Klaassen P., Platt D., Paddon C.J., Koetter P., van Ham R.C.,
RA   Reinders M.J.T., Pronk J.T., de Ridder D., Daran J.-M.;
RT   "De novo sequencing, assembly and analysis of the genome of the laboratory
RT   strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial
RT   biotechnology.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. Dihydroflavonol-4-reductase subfamily.
CC       {ECO:0000256|ARBA:ARBA00023445}.
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DR   EMBL; CM001536; EIW07406.1; -; Genomic_DNA.
DR   AlphaFoldDB; N1NWR8; -.
DR   HOGENOM; CLU_007383_9_2_1; -.
DR   Proteomes; UP000013192; Chromosome XV.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   CDD; cd05227; AR_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR   PANTHER; PTHR10366:SF853; NADPH-DEPENDENT ALDEHYDE REDUCTASE ARI1-RELATED; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          5..257
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   342 AA;  38228 MW;  87EC1B6AAD8C88D2 CRC64;
     MSVFVSGANG FIAQHIVDLL LKEDYKVIGS ARSQEKAENL TEAFGNNPKF SMEVVPDISK
     LDAFDHVFQK HGKDIKIVLH TASPFCFDIT DSERDLLIPA VNGVKGILHS IKKYAADSVE
     RVVLTSSYAA VFDMAKENDK SLTFNEESWN PATWESCQSD PVNAYCGSKK FAEKAAWEFL
     EENRDSVKFE LTAVNPVYVF GPQMFDKDVK KHLNTSCELV NSLMHLSPED KIPELFGGYI
     DVRDVAKAHL VAFQKRETIG QRLIVSEARF TMQDVLDILN EDFPVLKGNI PVGKPGSGAT
     HNTLGATLDN KKSKKLLDFK FRNLKETIDD TASQILKFEG RI
//