ID N4T736_HELPX Unreviewed; 681 AA.
AC N4T736;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HPHPA11_0104 {ECO:0000313|EMBL:ENH58978.1};
OS Helicobacter pylori Hp A-11.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992035 {ECO:0000313|EMBL:ENH58978.1, ECO:0000313|Proteomes:UP000012243};
RN [1] {ECO:0000313|EMBL:ENH58978.1, ECO:0000313|Proteomes:UP000012243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp A-11 {ECO:0000313|EMBL:ENH58978.1,
RC ECO:0000313|Proteomes:UP000012243};
RA Blanchard T.G., Czinn S.J., McCracken C.M., Abolude K.A., Shefchek K.S.,
RA Maroo A.M., Santana-Cruz I.S., Tallon L.J., Ficke F.W.F.;
RT "Comparative Sequence Analysis of H. pylori Isolates.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENH58978.1}.
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DR EMBL; AOTW01000001; ENH58978.1; -; Genomic_DNA.
DR RefSeq; WP_003012951.1; NZ_AOTW01000001.1.
DR AlphaFoldDB; N4T736; -.
DR PATRIC; fig|992035.3.peg.103; -.
DR Proteomes; UP000012243; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 9..270
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 271..539
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 681 AA; 77791 MW; 0E852B3A624C5833 CRC64;
MGFEKSILDH LNEAQKIAAS HIQGPLLILA GAGSGKTKTL TSRLAYLIGA CGVPSENTLT
LTFTNKASKE MQERALKLLK NQTLIPPLLC TFHRFGLLFL RQRMNLLKRA CDFSVLDSDE
VKTLCKQLKI SNFRASISQI KNGMMDLSMQ NSECYKAYEL YQNALKKDNL VDFDDLLCLS
LKILQDNEKL AKEISERYHY IMVDEYQDTN ALQLEFLKQL SFTHHNLCVV GDDDQSIYGF
RGADISNILN FSKHFKGAKI VKLETNYRSS TEILACANSL ISHNQHRHIK TLQSFKGSHK
SVVCKEYLTQ KEESLDVAYQ IKALLKKGEN LENIAILYRL NGLSRSIEES LNALNIPYRL
IGAVSFYERA EVKDALAFMH VVAKKDDRFF IKRVLNKPPR GLGKITQEWI FSLLDEEDLN
LEEALKLGVF KDKLNPKNEY ALKKFTAMIG RLREAFEISV EEFCAQFLEE TSLLKSYEKE
DNYEEREGFV KELLSLVKEH FKTNPTHSLL DFLNESVLDS HNTENVQKVS CMSVHMSKGL
EFKHVFVIGL EEGFFPHRGF NQESDLEEER RLAYVAITRA KEELQLSYVK ERSYFGRKIS
CSPSVFLEEA KLLKSDQTPK QNHQKNTPIK VGDLIKHKIF GTGRVLGVEK GLSGVCLKIN
CGGNVYDKIS EKFVEKVDNE F
//
