ID N4T8A6_HELPX Unreviewed; 856 AA.
AC N4T8A6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Chaperone protein ClpB {ECO:0000256|ARBA:ARBA00017574};
GN ORFNames=HPHPA11_0535 {ECO:0000313|EMBL:ENH59398.1};
OS Helicobacter pylori Hp A-11.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=992035 {ECO:0000313|EMBL:ENH59398.1, ECO:0000313|Proteomes:UP000012243};
RN [1] {ECO:0000313|EMBL:ENH59398.1, ECO:0000313|Proteomes:UP000012243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp A-11 {ECO:0000313|EMBL:ENH59398.1,
RC ECO:0000313|Proteomes:UP000012243};
RA Blanchard T.G., Czinn S.J., McCracken C.M., Abolude K.A., Shefchek K.S.,
RA Maroo A.M., Santana-Cruz I.S., Tallon L.J., Ficke F.W.F.;
RT "Comparative Sequence Analysis of H. pylori Isolates.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC {ECO:0000256|ARBA:ARBA00026057}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENH59398.1}.
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DR EMBL; AOTW01000001; ENH59398.1; -; Genomic_DNA.
DR RefSeq; WP_003014298.1; NZ_AOTW01000001.1.
DR AlphaFoldDB; N4T8A6; -.
DR PATRIC; fig|992035.3.peg.523; -.
DR Proteomes; UP000012243; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 4..144
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT COILED 409..489
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 856 AA; 96469 MW; B17A97B031728B8C CRC64;
MNLFEKMTDQ LHEALDSALA LALHHKNAEV TPMHMLFAML NNSQGILIQA LQKMPVDIEA
LKLSVQSELH KFAKVSQISK QNIQLNQALI QSLENAQGLM AKRGDSFIAT DVYLLANMSL
FESVLKPYLD TKELQKTLES LRKGATIQGK NDDSNLESLE KFGIDLTQKA LDNKLDPVIG
RDEEIIRMMQ ILIRKTKNNP ILLGEPGVGK TAVVEGLAQR IVNKEVPKTL LNKRVIALDL
SLLVAGAKYR GEFEERLKKV IEEVKKSTNV ILFIDEIHTI VGAGASEGGM DAANILKPAL
ARGELHTIGA TTLKEYRKYF EKDMALQRRF QPILLNEPSI NEALQILRGL KETLETHHNI
TINDSALVAS AKLSSRYITD RFLPDKAIDL IDEGAAQLKM QMESEPAKLS SVKRSIQRLE
MEKQALEMEK KESNAKRMQE ILKELSGLKE EKIQLEVQFE NEKEVFKEIS RLKMEMESLK
KEAERFKRNG DYQQAGEIEY SKIPENKKKE EELQHKWEAM QQNGALLQNA LTENNIAEIV
SQWTHIPVQK MLQSEKNRVL NIESELQKRV VGQEKAIKAI AKAIKRNKAG LSDSNKPIGS
FLFLGPTGVG KTESAKALAQ FLFDSDKNLI RIDMSEYLEK HSISRLIGAA PGYVGYEEGG
QLTEAVRRKP YSVVLLDEVE KAHPDVFNLL LQVLDEGHLT DSKGVRVDFK NTILILTSNV
ASGVLLEEDL SEADKQKAIK ESLRQFFKPE FLNRLDEIIS FNALDSHAII NIVGILFENI
QKKALERGIN ITLDEKAKEL IAEAGFDRFY GARPLKRALY EMVEDKLAEL ILEDKIKENG
SVAFVVENNE IVPKIK
//
