ID   N6T3V8_DENPD            Unreviewed;      1373 AA.
AC   N6T3V8;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
DE   Flags: Fragment;
GN   ORFNames=D910_01406 {ECO:0000313|EMBL:ERL84070.1}, D910_01414
GN   {ECO:0000313|EMBL:ERL84079.1}, YQE_08615
GN   {ECO:0000313|EMBL:ENN74844.1};
OS   Dendroctonus ponderosae (Mountain pine beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Curculionidae; Scolytinae; Dendroctonus.
OX   NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN74844.1};
RN   [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA   Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA   Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA   Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA   Birol I., Jones S.J., Bohlmann J.;
RT   "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT   a major forest pest.";
RL   Genome Biol. 14:R27-R27(2013).
RN   [2] {ECO:0000313|EnsemblMetazoa:ENN74844}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JAN-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GCN1 family.
CC       {ECO:0000256|ARBA:ARBA00007366}.
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DR   EMBL; APGK01044967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB741028; ENN74844.1; -; Genomic_DNA.
DR   EMBL; KB631073; ERL84070.1; -; Genomic_DNA.
DR   EMBL; KB631074; ERL84079.1; -; Genomic_DNA.
DR   STRING; 77166.N6T3V8; -.
DR   EnsemblMetazoa; ENN74844; ENN74844; YQE_08615.
DR   HOGENOM; CLU_000504_2_3_1; -.
DR   OMA; MMFRIAG; -.
DR   Proteomes; UP000019118; Unassembled WGS sequence.
DR   Proteomes; UP000030742; Unassembled WGS sequence.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:UniProt.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 6.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR   PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR   Pfam; PF02985; HEAT; 3.
DR   SMART; SM01349; TOG; 3.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   PROSITE; PS50077; HEAT_REPEAT; 3.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          60..296
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REPEAT          237..274
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          356..394
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          504..763
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REPEAT          704..741
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          951..1180
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ENN74844.1"
SQ   SEQUENCE   1373 AA;  150456 MW;  86998AB869D72389 CRC64;
     MGKSSKSANF DAVKQAVVVL MGCLARHLEK DDARIKPIFS RLIQALSTPS QTVQEAVANC
     LPPLATCVRD EAPGYINKLL HQLLKGDKYG ERKGAAYGLA GIIKGLGILA LKQNDIMSKL
     TDAVQDKKNY KHREGALFAF EMLFQMLGKL FEPYIVHVLP HLLQCFGDTS QYVRDAAHDT
     SRVVMGKLSG HGVKLVLPSL LEALEEDSWR TKTGSVDLLG TMAFCAPKQL SSCLPSIVPK
     LIEVLSDSHM KVQESGAKAL KVIGSVIRNP EIQAIVPVLL RALQDPSNKT SVCLQTLLDT
     KFVHFIDAPS LALIMPVVQR AFMDRSTETR KMAAQIIGNM YSLTDQKDLM PYLPTIIPGL
     KTSLLDPVPE VRSVSARALG AMVRGMGETT FEDLLPWLMK TLTSESSSVD RSGAAQGLSE
     VVGGLGVEKL HKLMPDIINT AERTDIAPHV KDGYIMMFIY MPSVFTPEFT QYIGQIINPI
     LKALADENEY VRETALKAGQ RIVNLYAESA ILLLLPELEK GLFDENWRIR YSSVQLLGDL
     LYRISGVTGK MSTETASEDD NFGTEQSHLA IINALGRETR NRVLAGLYMG RSDVALMVRQ
     AALHVWKVVV TNTPRTLKEI LPTLFNLLLG CLASDSYDKR QVAARTLGDL VRKLGERVLP
     EIIPILEEGL ESERADQRQG VCIGLSEIMA STSKDMVYTF VNSLVPTVRR ALCDPLPEVR
     QAAAKTFDSL HSTVGSRALD DILPNLLSQL NDDDPAVVEC TLDGLRQVMA IKSRVVLPYL
     VPQLTAPPAN TKALSILASV AGEALNKYLP RILPALQKAL ATSKGTPEEA QELEYCQAVI
     LSVVDDVGIR TVIDTMLQNT KTEDADQRRA AATLLCAFCA NSKAQYAAHV PQLLRGLIFL
     MTDNDRDVLQ RAWEALNAVT KTLEPKQQAA YVSDVRQAVR YAMSDLKGIS DLLPGFCLPK
     GIVPILPIFR EAILNGDGDE KDAAAQGLGE IIRVTNSTAL QPSVVAITGP LIRILGDRFG
     ANVKTAVLET LATLLSKVGS MLKQFLPQLQ TTFLKALNDP SRTVRLKSAA ALGELIPIHQ
     RADPLFTELH NSIKNNEDAA VKETTLHALR GIITPAGDKM SEPIKKQIHA TLLTNLGQSE
     ENVRKCAAGC LGAICKYLSP EQLDATLSEH LLNDDASANM TLREGRGFAL TVALKEAPER
     LWDEQYKMKL SQVLLSQFQS QVVSITQSAI RSCGYLLEYI ISNGEAIPNN VLVAFVRTMN
     NTNNEVKQLL ARVLFHLAKI IPTEKFTSDF LRLVLPTLVN GTKEKNVYVK ANSEIALIAI
     LKLKNGDSVF LKMSNSLDIG ARESLSDVVN KVLKKMLHQP EGKDEDIDDT LLT
//