ID N6T9G3_DENPD Unreviewed; 2598 AA.
AC N6T9G3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=YQE_06735 {ECO:0000313|EMBL:ENN76894.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN76894.1};
RN [1] {ECO:0000313|EMBL:ENN76894.1, ECO:0000313|Proteomes:UP000019118}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN76894}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR EMBL; APGK01039175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740967; ENN76894.1; -; Genomic_DNA.
DR EnsemblMetazoa; ENN76894; ENN76894; YQE_06735.
DR HOGENOM; CLU_000178_2_8_1; -.
DR OMA; SMYIGWC; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1531..2102
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2257..2568
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2566..2598
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT COILED 1209..1236
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN76894.1"
SQ SEQUENCE 2598 AA; 297124 MW; 4E44AA596384233E CRC64;
MTANPIPYFL NVMESPVLQD VFPTWKMVDE LVDTLLKTGA TDKNSIQTLA NMAMSEQFSR
TFIYNKEADL SFQEYQAIVD KYQTFTTWLL GQFFYLLSRD NNEIIVDAQL SIINQLSRTQ
LHVYAYLADE YCRALNILCG YLKDCSKPRR IDVFEPKRNE ELSKSLNLKS ATIELTSEKT
CLQLIKKLLK IVKYILIESF TFNCLDQATV TALDNILFLL RNEHWNLDVI AVFIDLLGRL
NYNIKVLDLQ IVQLFKAFFS LFEQYVYDFY GNGNKSKVDK DAFEDLLFRY LEECRSLKAD
IHQNDARIAS FLIKLSLESR PGPAELTPGK EIQIASAKYF SQTVSSMASL AMANISTVIT
RNDSVIFSLL EPQIFKETCS YMTSHSHATV VEVMEISETW KQICFALNSS WLSLQCSPSI
CQMQSRLEFF VDICASLARL KFRIYSHYNS NEYIVNFFSG SVILPKVLSN IAKHSISCHS
LIKPLKVLEF LVKHLGVTEC KNLDIFFHLI SCRILPGPGY ATGALPNNYQ GPIEERSKLK
ADINCLYDFI RGNKHISNVD VLANTTAFFD ILSSGLVKNL NDSHMEQIEA VHLNVLKNLR
NSEDTQVLES IPVLLNVFSA KDDIVKNILL PLLPTKHNSV QQTVAKIIPL LLCCSLSDFV
KVVTTDSIQI ICQECATDSK NAASRTGVYR IKFSRNGADI SSVAVTLLKT VINYLINPSE
DLKKRAIQCM PSLAQHVPKF FTVDVTKIWI EKVGDSSVEV RKVLGKDVRR IIANGLGNPA
ISKEIKDKVL EMMFSVLLRL SKRSLQFSEF ELQDTLLDTI SEISRIEHES IKLQCMKILL
YFVMVPTSFQ SFIAVNRCVG LSKNDSAGHL LVYKHHSDTL CEVIVHLCYS NQYIIKASLQ
ESLVKVSAML GFDGVKDFVA KEVNKLLPFL VAKTVKNNNV RKLIEEMASI ISVDVSDMLI
TNYGHIFLYL FLGDVDRADS KKCLNYLEAT TKLSGPKLRK LNFKVLLNEL LLNFHEKRQK
VLTTFQLLLA EDNLSQGKSI EDYLEPYFLA FLLYFNLELT SEYSKKEKML LSLADLLKFL
GPNRIMPLRF KILAMLQATH YLKHPALTCI VWEAFIRSCE PDYLGPHLAT IFASMLPLIE
KCPNDVNKIF RYLILENEAT LRDYIADLFF VNNHFLSPNI SIVIRKHVKT TEKLALKAKI
QRYLKYLKHD SLEVRVQSLR QLKSCLEQNR EELDQMVLGY NGIDSTIVEL IDYLTLACRT
KEVALKLACG DIFGELGAIE PSHLPRRCAQ DSQSFNFFIS DDAFIESAIN ELIKSFQTDK
NARNTDRVAL AIQEILKTYE ISPNPDSARN DMWTRFPEAH REVMTPLLSS KYICVEKFVG
YPCPVYGSGD GSSFQAWLYN WTSSLISTLS PEKRSLLQSC FPSMKLDQRV LMHFLPYIVL
HSLVDSVNSN EEKCYVEFEF ILNGFNKLRD VDEKILSNRP LPVPGQTPIA RELTGDSEKQ
IKCAKVVFIL LDFLDRWLRE WQFLAKFCKL QVAKCNYKCG EYSRALMYLE DYITESPDQV
LPNLQFLGEI YAQLDEPDGV LGVEPLQQSE PSLEQKLLSL KVSGKLNDAA AIYEHMPRPL
KLQHVQNLIQ CYLDLDKVNT ALYCAEGALG LQPEFGNMLL DMQAEALWRL GTYENLDRLL
ANPDVDNCKG WGVQVGKSLL CIKNEERDEF KRVLESIKKQ QVDSFGAASL EEGAYHHGYS
YIAHLHCLNE LEQLEQKLVD LFLKPNDRNY AESIVQKLAN EWQLRIKVVQ ESVRVVEPLL
CLRRVALNLA RDIAERKAPQ AVPHLENLLG ETWLKSVNVA RRAGMHQQAY TYVLDAEKYN
PPKLFIEKAK LHWLREEHEE ALNTLKRGLH CYIPDGSSNE EALQAIANLS VEQKKLCAEA
RLLIASYNKD ICSVDVETNL QQYKDAVEVC KEWEKSLVCL AQYQDRIFQN YNNEEKDSKA
NELQLHIVHN FGKSLYFGTT YIYQSMPRLL SIWFDCGTRL SNVASSAPKE ERRLVLVKMT
KIIDSFLNKL PAFVFLTSFS QIISRIAHPQ KEVYVQLKSI IVNLMLHYPQ QCLWMISSVI
KSSYPIRAKR CAEILNDPLL KMQPISRIIR DFTSLTEKLI ELCNKEISSD VHNASVNLLV
RSLPRYGEVD FSAFFWKILI CTDWCRTNND NFDTKLLNKD FSEIMMPTHK FRKLILPNPD
IKNAQSHHNP FPNHYWGLTT TLAYCRACSA PGRSALKDPT AKGQPPLLAP QRLQLFSSFS
YTFMLKPKDD LRKDFRLMEF NDIVNHLLLR DAEARQRRLN IRLYSVAPLN EECGLIEWVH
DLVGLRHILM NIYKQRGLGM RPREIKEVCC SIRDSIGKKR NVFQNILVKR HPPVLGEWFR
KTFPDAQTWL TARTAYTRTN AVISITGYML GLGDRHGENI LLDATCGDVV HVDFNCLFNK
GETFEWPERV PFRLTQNMIA AMGPLGVEGV FRQASEFTLG VLRSNTSTLM SIVTPFVYDP
LVSWPRNVPA AAQSSEKVNE QALEHIKNIE LRLQGKVKTR SRTMSQCLSI EGQIEHLINE
AKSSDNLCQM YIGWGPYL
//
