ID N6TW91_DENPD Unreviewed; 670 AA.
AC N6TW91;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Protein vav {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=YQE_10749 {ECO:0000313|EMBL:ENN72651.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN72651.1};
RN [1] {ECO:0000313|EMBL:ENN72651.1, ECO:0000313|Proteomes:UP000019118}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN72651}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
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DR EMBL; APGK01052664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB741213; ENN72651.1; -; Genomic_DNA.
DR AlphaFoldDB; N6TW91; -.
DR EnsemblMetazoa; ENN72651; ENN72651; YQE_10749.
DR HOGENOM; CLU_013787_0_0_1; -.
DR OMA; PDKANHN; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR CDD; cd21201; CH_VAV; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022771};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 12..131
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 175..354
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 512..618
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 618..670
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN72651.1"
SQ SEQUENCE 670 AA; 78032 MW; A0810A98D7702B52 CRC64;
MALARNYSDS NDELWKECVH WLTRWEIIRP DHKLNWESAH IADLAALLRD GVILCKLLCK
IDPGCIDIKD VNLKPIMAQF LCLRNISIFI KACKNSFGLS PADLFEESML FELTNFHKVL
CTLSKLSKTE KAESSGILQP SAPRGLDIGS SIVTDSGVTS EEIYQDLLQS QPQEKRDFVI
KELLDTEKNY VDVLNKLKVS FMTPLQSQMK PEHHSQVFYK IKELYEVHSG FLLEMVKIRT
NNNVKLGQLF QNFKEKFLIY GGYCANLTKA TSLLQELCDE DENFNQTIIS YEKEVNNGRF
KLRDVLSVPM QRILKYHLLL EKLIELTDKN HDEYSELKTA WESMLDVARY INEAHRDVEH
LNVINNLQET ILEWEHDPDM RLSDYGKLRK DTELKIKAHD DQKTRNRYVF IFDKCILICK
QLKGNQFAYR DILNIMEYHV EEIHNRAILN NQGRRSYSFL LVKHAQEMAY TIYVRTLELK
DQVIKAIAEA QLVPPAAPLT PIERDPLATK LWYVGEMERT VARNKLMYRE DGTFLVRMSI
DSAGTKSGDY AVSLQYNGSA KHMRISMIDD GPGDAKKYFL SVSRFFSSIE DLIKYYENHS
LRENFALLRE DTRLLYPFRQ LRAIVLKNYD AQTRDELSVR EGQVLKVLEQ DGYRDGWWKG
RTGDNRVSFF
//
