ID N6UDS0_DENPD Unreviewed; 766 AA.
AC N6UDS0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
DE Flags: Fragment;
GN ORFNames=YQE_06648 {ECO:0000313|EMBL:ENN76807.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN76807.1};
RN [1] {ECO:0000313|EMBL:ENN76807.1, ECO:0000313|Proteomes:UP000019118}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN76807}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; APGK01039092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740967; ENN76807.1; -; Genomic_DNA.
DR AlphaFoldDB; N6UDS0; -.
DR EnsemblMetazoa; ENN76807; ENN76807; YQE_06648.
DR HOGENOM; CLU_012574_2_1_1; -.
DR OMA; SNEHGRD; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF07657; MNNL; 1.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 580..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 169..213
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 280..318
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 320..358
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 365..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 403..442
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 444..481
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 483..519
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 521..557
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 615..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 171..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 184..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 204..213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 308..317
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 329..346
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 348..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 391..400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 432..441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 471..480
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 509..518
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 547..556
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN76807.1"
SQ SEQUENCE 766 AA; 82511 MW; D0695238208585BF CRC64;
MAHSNTLSSG VFELRLLSFD NQAGKDDLGK CCSGRPSGLE CEGDCRPRFR ICLKEYQVKI
DATSPCTFGD VITSELGPGP ADDPQSGFAN AIAMRFPFTW PVRIFNVLIP FFELGTFSLI
VEAWHGNQSA HSAVLVSRLM RQRYLDVSEQ WTEDTHSSKY STLRFEYRVT CEPHYYGKGC
EDLCRPRDDS FGHYSCSPSG ERVCLAGWTG DYCTKAQCLP GCDEQHGHCT RPNECKCQSG
WEGPLCDKCQ RYPGCMHGSC VKPWDCLCDD GWGGLFCNQD LNFCTNHLPC RNGGTCFNTG
EGSYTCSCPP GYNGTDCEVA TDDCARTPCL HGGTCLKSEN SDTFVCQCTS GYGGSICQTP
LPLPTAPGCS GNPCNNGGSC QDVSGGYRCT CRPGFTGPSC ERHLGVCDPT PCENGGVCSE
ATGAPHGFRC ACPAGFVGDR CQVDVDDCAG GNPCLNGGTC IDKVNEFRCQ CVPGFASRLC
QDRVDYCIAK PCANGGTCHQ LLNDYECRCP PGFGGKDCSI EVDECRSDPC KNGGTCVGRP
RGYECICPVG FLGRDCVESS AGAASSARIS TESTLTAEHV IVIATISTFV PLLALIAVGA
IACLKHRRKR EKARADEEAR LQNEQNTANS SFAKRGAAMA ADARMIKNSW GKCTNNAIEE
ANVGDLEPFP KQQQQVIDGR PVYGLQRSRS QKQLNTESSS TATSAAVAAA RASALLVAKL
HEPDYEPIKR LSVMSHSDPP LKDAPVFVVE EHFRVPVSGG LFATEV
//
