ID N6UHB5_DENPD Unreviewed; 1584 AA.
AC N6UHB5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE Flags: Fragment;
GN ORFNames=D910_02640 {ECO:0000313|EMBL:ERL85219.1}, YQE_02473
GN {ECO:0000313|EMBL:ENN81105.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN81105.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN81105}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; APGK01020350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740193; ENN81105.1; -; Genomic_DNA.
DR EMBL; KB631669; ERL85219.1; -; Genomic_DNA.
DR STRING; 77166.N6UHB5; -.
DR EnsemblMetazoa; ENN81105; ENN81105; YQE_02473.
DR HOGENOM; CLU_000315_8_1_1; -.
DR OMA; YLWHRNE; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18666; CD1_tandem_CHD1-2_like; 1.
DR CDD; cd18659; CD2_tandem; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR InterPro; IPR040793; CDH1_2_SANT_HL1.
DR InterPro; IPR025260; CHD1-like_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623:SF14; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR Pfam; PF18375; CDH1_2_SANT_HL1; 1.
DR Pfam; PF13907; CHD1-like_C; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 2.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01176; DUF4208; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 174..267
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 292..353
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 395..537
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 666..817
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1205..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1404..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..1007
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1556..1584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN81105.1"
SQ SEQUENCE 1584 AA; 184373 MW; D9DCFB9E81CC7406 CRC64;
MNEEYTQQAS QFVSSIPGPS EEQFRSDSSK DHNSEVLIYN IFAIPEIRRS ARSKREPPRP
DGNSKIRTSR DEWKYNDASS SESDSERERP PPSKRVGARS RATAQKRIVT RKTRYSSDES
TDGDSEDEKR RTVSRRTAAA VSYKEDSEEK TDSEDLVEVD PSELIEPVTE EKCETIERVL
AQRRGKKGVT GNITTCYYVE EHGDLNADVN PNDYENTEYQ FLIKWKDWAH IHNTWESEQT
LKEQKVKGIK KLDNYMKKDA EIQKWISYST PEDVEYYECQ LELSQELLKS YNEVERIIAM
YNKPDGGTDF FVKWESLSYA ESTWEDSLLI HRKWPQKVQE FQGREQSTKT PTKHCKVLKY
RPKFHEVKSQ PEYMMGKENA LVLRDYQIHG LNWMIHSWTK ENSVILADEM GLGKTIQTIC
FLYYLFNTHN LHGPFLCVVP LSTMTSWQRE FAQWAPELNF VTYLGDVQSR EIDKAFLGSL
SWAVLLVDEA HRLKNDDSLL YKALMEFHTN HRLLITGTPL QNSLKELWAL LHFIMPNKFV
TWEEFEKDHE HASTKGYSKL HKQLEPFILR RVKKDVEKSL PAKVEQILRV EMTSIQKQYY
KWILTKNYNA LRKGVKGSSN TFLNIVIELK KCCNHAFLTK PSEAEPQYTC QDKLQSLLRG
SGKLVLLDKL LIRLKETGHR VLIFSQMVRM LDILAEYLQL RHFPFQRLDG SIKGDIRRQA
LDHFNADGSP DFCFLLSTRA GGLGINLATA DTVIIFDSDW NPQNDLQAQA RAHRIGQKNQ
VNIYRLVTAR SVEEEIVERA KQKMVLDHLV IQRMDTTGRT VLNQKASTNN NPFNKEDLTA
ILKFGAEELF KDEDVDEEPN CDIDEILRRA ETRDEAPSMV GDELLSAFKV ASFAAFDEDA
TPSPVRTKNE NDEESKDWDE IIPENLRKKV EDEERNKEME DLYLPPRNRK TLQQINQSES
DGDGAEHRKT NKKENDESGS SIEGEESDDE RPKRRGRPPV GNREKIKNFT DAEIRRFVKS
YKKFSAPLKR LEAVACEAEL QEKPLAELRK LGELLHERCV AYMNEQSKEN NDANNADNQG
KKRIRGPSFK LGGVSVNAKT MMQCEEELAA LDELLPTNED ERNKWMLEVR TKPAHFDVEW
GAEEDSKLLR GIYVYGIGSW EQIKLDPSLK IGDKVLLNED KKPQAKHLQS RAEYLLKLLK
KQLDPNKKVQ KPKRPRKAKE IKDAKSKEIV DNDFSSNDES TLHSSQSVSS STAKKVKVPV
VKKEINNDKD AEDVAIKKEK KEKKKAKKEK KSAGPMHFTA NNEPKAINVL GDLDPAIFTE
CKERMRPVKK ALKALDNPDQ SMTESEQVQH TRECLIQIGE QINTVLGQYT DAEKIKEWRS
NLWYFVSKFT EYDAKKLYKL YKKAKAKDAK KAEKKEKLEK KDRNREQVAS TSKEKDRTRK
DSDKEPHYHH HHKRKHEPEE NNEREERPTK KHRDGTEKRE RREKHPDKDR KRNREEISTE
EEGEYRYNRH RTAPTFRHTA PPVHLEHERW SATGLPRERF PGEHPKRPFS DYPRVPGYHR
GERDYNRGDK RNSADNEKRT FKFI
//
