ID N6UHX9_DENPD Unreviewed; 495 AA.
AC N6UHX9;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Disks large 1 tumor suppressor protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=YQE_03338 {ECO:0000313|EMBL:ENN80236.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN80236.1};
RN [1] {ECO:0000313|EMBL:ENN80236.1, ECO:0000313|Proteomes:UP000019118}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN80236}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; APGK01024852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01024853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01024854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01024855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01024856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01024857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01024858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01024859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01024860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740563; ENN80236.1; -; Genomic_DNA.
DR AlphaFoldDB; N6UHX9; -.
DR EnsemblMetazoa; ENN80236; ENN80236; YQE_03338.
DR HOGENOM; CLU_001715_4_1_1; -.
DR OMA; CHISAHI; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd11861; SH3_DLG-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF51; DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 35..116
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 148..218
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 304..480
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 210..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN80236.1"
SQ SEQUENCE 495 AA; 55755 MW; 28D0B434CC7F6CB1 CRC64;
MTKKNSRERS PIRAGFATIS RRFKNKEKLK REVRTVTLQK SSTGLGFNIV GGEDGEGIFV
SFILAGGPAD LSGELKRGDQ IISVNGVNLR NATHEDAAQA LKGTSQTVTI VVQYRPEEYN
RFEAKINDLK QQMANPVTGG TLLRTSQKRS LYVRALFDYD PVKDDGLPSR GLAFQYGDIL
HVTNASDDEW WQARRVLASG DEQGMGIVPS KRRWERKQRA RDRSVKFQGQ GGQAEKQSTL
DRKKKSYSFS RKFPFMKSKD EKSEDGSDQE PFMLCYTQED SNNEGNEETV LSYEAVQQMQ
IQYTRPVIIL GPLKDRINDD LISEFPEKFG SCVPHTTRPK REYEVDGRDY HFVASREQME
KDIQNHLFIE AGQYNDNLYG TSVSSVREVA EKGKHCILDV SGNAIKRLQV AQLHPVAIFI
KPKSVESIMN RPGGLTNILV IQTFLPQCIG LCHISAHIFS AVVQGDTPED IYAQVKDIVN
EQSGPTIWIP AKEKL
//
