ID N6Y2V1_9RHOO Unreviewed; 630 AA.
AC N6Y2V1;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Propionyl-CoA synthetase {ECO:0000313|EMBL:ENO76453.1};
DE EC=6.2.1.17 {ECO:0000313|EMBL:ENO76453.1};
GN Name=prpE {ECO:0000313|EMBL:ENO76453.1};
GN ORFNames=B447_17786 {ECO:0000313|EMBL:ENO76453.1};
OS Thauera sp. 27.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Thauera.
OX NCBI_TaxID=305700 {ECO:0000313|EMBL:ENO76453.1, ECO:0000313|Proteomes:UP000013140};
RN [1] {ECO:0000313|EMBL:ENO76453.1, ECO:0000313|Proteomes:UP000013140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=27 {ECO:0000313|EMBL:ENO76453.1,
RC ECO:0000313|Proteomes:UP000013140};
RA Liu B., Shapleigh J.P., Frostegard A.H.;
RT "Draft Genome Sequences of 6 Strains from Genus Thauera.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENO76453.1}.
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DR EMBL; AMXB01000039; ENO76453.1; -; Genomic_DNA.
DR RefSeq; WP_002943693.1; NZ_AMXB01000039.1.
DR AlphaFoldDB; N6Y2V1; -.
DR eggNOG; COG0365; Bacteria.
DR Proteomes; UP000013140; Unassembled WGS sequence.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR012694; Propion_PrpE.
DR NCBIfam; TIGR02316; propion_prpE; 1.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:ENO76453.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000013140}.
FT DOMAIN 4..58
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 60..440
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 511..594
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 630 AA; 69825 MW; 3AF82B3A3A392A3F CRC64;
MTDYQQFHRR SIEDRDGFWA EQAQLVHWNK PAEQICDFSK PPFVKWFKGG ETNLCFNAVD
RHAATRPNDR ALVYISTETN EEKVYSFAEL QREVERMAAI YQDLGVKRGD RVLIYMPMIA
EAAFAMLACA RIGAIHSVVF GGFAAGSLAT RIDDAKPVLM VSSDAGMRNG KPVPYKHLVD
EACKLAEFPP AKVLIVDRGL DKGFPRVEGR DVDYAELRAR HMDAQVPVVW LESSEPSYIL
YTSGTTGKPK GVQRDTGGYL VALASTMPHI FTGEAGETMF ATSDIGWVVG HSYIIYGPLI
GGMATIMYEG TPLRPDAGIW WQIVEKYKVS VMFSAPTAVR VLKKQDPAFL KKYDLSSLKH
LFLAGEPLDE TSHEWIMREL GIPVIDNYWQ TETGWPMLAI CRGVEDSPIK LGSPAFPVYG
YDLRIFREDG SECGANEKGI VGIVPPLPPG CLSTVWGQDE RFVSTYFSTF QDPIVYSSSD
WGIRDDKGYY TILGRMDDVI NVAGHRLGTR EIEEAVQTHP AIAEVAVVGV HDELKGQMPM
AFAVVKDAST VDTAEKRAAL EKEVMKKVDE SLGAIARPAR VHFINGLPKT RSGKMLRRSI
QALAEGRDAG DLTTIDDPST LEQIKVALKG
//
