ID N6YAH4_9RHOO Unreviewed; 737 AA.
AC N6YAH4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=C664_12690 {ECO:0000313|EMBL:ENO76974.1};
OS Thauera sp. 63.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Thauera.
OX NCBI_TaxID=497321 {ECO:0000313|EMBL:ENO76974.1, ECO:0000313|Proteomes:UP000013007};
RN [1] {ECO:0000313|EMBL:ENO76974.1, ECO:0000313|Proteomes:UP000013007}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=63 {ECO:0000313|EMBL:ENO76974.1,
RC ECO:0000313|Proteomes:UP000013007};
RA Liu B., Shapleigh J.P., Frostegard A.H.;
RT "Draft Genome Sequences of 6 Strains from Genus Thauera.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENO76974.1}.
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DR EMBL; AMXC01000014; ENO76974.1; -; Genomic_DNA.
DR RefSeq; WP_004260925.1; NZ_AMXC01000014.1.
DR AlphaFoldDB; N6YAH4; -.
DR eggNOG; COG0210; Bacteria.
DR OrthoDB; 5905204at2; -.
DR Proteomes; UP000013007; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 6..287
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 288..563
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 737 AA; 82367 MW; 6F28A4EA651E6434 CRC64;
MSNLLANLNS EQLQAVTLPS QHALILAGAG SGKTRVLTTR IAWLIQSGQV DPAGILAVTF
TNKAAKEMLA RLSTMLPVST RGMWIGTFHG LANRLLRAHH RDAGLPQLFQ ILDSGDQLAA
IKRLLKTLNV DDEKFPPREL QHFINGQKEA GNRPHAVEAW DDYTRQRVQL FQEYETQCQR
ESVVDFAELL LRSYELLERN EPLRRHYQRR FRHILVDEFQ DTNRLQYRWL KLFADEGREG
GAAMFCVGDD DQSIYRFRGA EVGNMRDFER EFRVQNVIRL EQNYRSHSNI LDAANAIIRH
NSNRLGKNLW TDQGAGEPIR VFEAFSDGDE ARWIVEEIQS LVRDGALRSE TALLYRSNAQ
SRVLEHQLFS AGIPYRVYGG LRFFERQEVK HALAYLRLIA NPDDDTSFAR VVNFPTRGIG
ARSLEVLTDA ARVYNTSLYA TVPHLTGKPG TSLAQFVRLV EDLRRDTASL PLPELVDHVL
DLSGLRGHYK ADKEGRERLE NLDELINAAA NFLAESQADA DALAQPHALL ADFLAHASLE
AGDHQADQGA DAVQLMTVHA AKGLEFNVVF LSGLEEGLFP HENSILETDG LEEERRLMYV
AVTRARERLY LSFAQSRMLH GQTRYNLRSR FLEEIPAELT KWLTPPNPRS AAGGAMGGMG
GGYFKPSSAS QVQRAPRPTF ATLPNGLRIG QSVSHAKFGQ GVIVAAEGSG ADAKVQINFG
PAGVKWLLLA VAKLEPV
//
