ID N8R2H6_9GAMM Unreviewed; 701 AA.
AC N8R2H6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:PJF05378.1};
GN ORFNames=CVD06_02210 {ECO:0000313|EMBL:PJF05378.1}, E2R16_09210
GN {ECO:0000313|EMBL:TEU27529.1}, F985_00350
GN {ECO:0000313|EMBL:ENU45146.1}, IC763_01740
GN {ECO:0000313|EMBL:QNY27791.1}, IC769_01750
GN {ECO:0000313|EMBL:QNY06720.1}, IC776_16595
GN {ECO:0000313|EMBL:QNX72015.1}, IC779_18130
GN {ECO:0000313|EMBL:QOD72920.1}, IC795_01640
GN {ECO:0000313|EMBL:QNX09047.1}, IC796_01760
GN {ECO:0000313|EMBL:QNX05722.1};
OS Acinetobacter seifertii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=1530123 {ECO:0000313|EMBL:ENU45146.1, ECO:0000313|Proteomes:UP000013065};
RN [1] {ECO:0000313|Proteomes:UP000013065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIPH 973 {ECO:0000313|Proteomes:UP000013065};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter sp. NIPH 973.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ENU45146.1, ECO:0000313|Proteomes:UP000013065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIPH 973 {ECO:0000313|EMBL:ENU45146.1,
RC ECO:0000313|Proteomes:UP000013065};
RX PubMed=25563912; DOI=10.1099/ijs.0.000043;
RA Nemec A., Krizova L., Maixnerova M., Sedo O., Brisse S., Higgins P.G.;
RT "Acinetobacter seifertii sp. nov., a member of the Acinetobacter
RT calcoaceticus-Acinetobacter baumannii complex isolated from human clinical
RT specimens.";
RL Int. J. Syst. Evol. Microbiol. 65:934-942(2015).
RN [3] {ECO:0000313|EMBL:PJF05378.1, ECO:0000313|Proteomes:UP000229898}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MI30-324 {ECO:0000313|EMBL:PJF05378.1,
RC ECO:0000313|Proteomes:UP000229898};
RA Cerezales M., Xanthopoulou K., Ertel J., Nemec A., Bustamante Z.,
RA Seifert H., Gallego L., Higgins P.G.;
RT "Acinetobacter seifertii isolated from Bolivian hospitals; a case of
RT mistaken identity.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:TEU27529.1, ECO:0000313|Proteomes:UP000297445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAb133 {ECO:0000313|EMBL:TEU27529.1,
RC ECO:0000313|Proteomes:UP000297445};
RA Furlan J.P.R., Stehling E.G.;
RT "Draft genome sequence of an environmental Acinetobacter seifertii from
RT Brazil.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Proteomes:UP000516666, ECO:0000313|Proteomes:UP000516688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AS23 {ECO:0000313|EMBL:QNY06720.1,
RC ECO:0000313|Proteomes:UP000516688}, AS39 {ECO:0000313|EMBL:QNX72015.1,
RC ECO:0000313|Proteomes:UP000516666}, AS4
RC {ECO:0000313|Proteomes:UP000516799}, AS42
RC {ECO:0000313|EMBL:QOD72920.1, ECO:0000313|Proteomes:UP000516672}, AS72
RC {ECO:0000313|EMBL:QNX09047.1, ECO:0000313|Proteomes:UP000516745}, and
RC AS73 {ECO:0000313|EMBL:QNX05722.1, ECO:0000313|Proteomes:UP000516862};
RA Li L.-H., Yang Y.-S., Sun J.-R., Huang T.-W., Huang W.-C., Wang Y.-C.,
RA Kuo T.-H., Kuo S.-C., Chen T.-L.;
RT "Clinical and molecular characterization of Acinetobacter seifertii in
RT Taiwan.";
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|Proteomes:UP000516666, ECO:0000313|Proteomes:UP000516672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AS23 {ECO:0000313|EMBL:QNY06720.1,
RC ECO:0000313|Proteomes:UP000516688}, AS39 {ECO:0000313|EMBL:QNX72015.1,
RC ECO:0000313|Proteomes:UP000516666}, AS4 {ECO:0000313|EMBL:QNY27791.1,
RC ECO:0000313|Proteomes:UP000516799}, AS42 {ECO:0000313|EMBL:QOD72920.1,
RC ECO:0000313|Proteomes:UP000516672}, AS72 {ECO:0000313|EMBL:QNX09047.1,
RC ECO:0000313|Proteomes:UP000516745}, and AS73
RC {ECO:0000313|EMBL:QNX05722.1, ECO:0000313|Proteomes:UP000516862};
RA Chen F.-J., Lee Y.-T.;
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QNY27791.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AS4 {ECO:0000313|EMBL:QNY27791.1};
RA Li L.-H., Yang Y.-S., Sun J.-R., Huang T.-W., Huang W.-C., Wang Y.-C.,
RA Kuo T.-H., Kuo S.-C., Chen T.-L.;
RT "Clinical and molecular characterization of Acinetobacter seifertii in
RT Taiwan.";
RL Submitted (MAR-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
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DR EMBL; APOO01000002; ENU45146.1; -; Genomic_DNA.
DR EMBL; PGPD01000010; PJF05378.1; -; Genomic_DNA.
DR EMBL; CP061561; QNX05722.1; -; Genomic_DNA.
DR EMBL; CP061565; QNX09047.1; -; Genomic_DNA.
DR EMBL; CP061646; QNX72015.1; -; Genomic_DNA.
DR EMBL; CP061672; QNY06720.1; -; Genomic_DNA.
DR EMBL; CP061687; QNY27791.1; -; Genomic_DNA.
DR EMBL; CP061828; QOD72920.1; -; Genomic_DNA.
DR EMBL; SNSA01000004; TEU27529.1; -; Genomic_DNA.
DR RefSeq; WP_004705224.1; NZ_SNSA01000004.1.
DR PATRIC; fig|520709.3.peg.341; -.
DR HOGENOM; CLU_012300_3_0_6; -.
DR OrthoDB; 9805041at2; -.
DR UniPathway; UPA00908; UER00886.
DR Proteomes; UP000013065; Unassembled WGS sequence.
DR Proteomes; UP000229898; Unassembled WGS sequence.
DR Proteomes; UP000297445; Unassembled WGS sequence.
DR Proteomes; UP000516666; Chromosome.
DR Proteomes; UP000516672; Chromosome.
DR Proteomes; UP000516688; Chromosome.
DR Proteomes; UP000516745; Chromosome.
DR Proteomes; UP000516799; Chromosome.
DR Proteomes; UP000516862; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015970; P:guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:PJF05378.1}.
FT DOMAIN 51..148
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 379..440
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 701 AA; 79671 MW; 2E32A384F5550FBD CRC64;
MPGEEVSQAK QQLKLIIEPY LSVSEVEKVL AACDFGDLAH TGITRKSGEP YILHPIAVSC
ILANMRLDAE TLMAALLHDV IEDTQYTKED ITERFGQTVA ELVDGVTKLS QSSDKEYNKA
ASFRKILQAT LQDPRVIIIK LADRYHNMTT LGALRPDKRA RIAQETFDIF VPMARLVGMN
EMADNLENLC YQNLDLDMFD NVQNALLQTK PERCKYQSIW EQNLAELLHN YHIQGRIKKK
NNNIELLRHF VKSEMDLQEL THSHAFEIVL QSVADCDRLF AALKENFQVI EYQDHIRRPL
PGGNQSLLIK LKGEKTTLSL TIQTELMRKA ARFGVVLGEN APQTCRSAIQ ASMQNLNTLI
DGECAKTTFN DLLDYLHQEK IWVYTPHGQL HELPQGATVV DFAYSASLFL GNHAVGAKVD
GEIKPLSTPL VSGQVIEIIT DVLATPNPDW LSFINTQKAR RALQHVLKDQ DIEEQRLVGA
QALSRALKLF NRSINDLSEA DWLDLLQWRH IDNKDALFEQ IAVGDLLPQL VANHLFANDK
HPQVENSDRL IQGTEGIDVK YAHCCNPVLG DLIQGHLTRR GLIVHRIRCH NLLHEQHLHP
ENIMPLQWKA DDVDDVRFTA YLAIYMAMND EQVSDLIYQC RKNNAGVEMV HSNEQRTFFN
IVVNNRKHIA KVIRDLRMHY GFPRIERLDA PAPQAEISKV S
//